76905-09-4Relevant academic research and scientific papers
A novel one-pot procedure for the stereoselective synthesis of α-hydroxy esters from ortho esters
Breunlng, Matthias,Haeuser, Tobte,Tanzer, Eva-Maria
supporting information; experimental part, p. 4032 - 4035 (2009/12/09)
A novel one-pot procedure for the stereoselective synthesis of a-hydroxy esters from ortho esters was developed. Key steps were multiheteroatom Cope rearrangements of O-acylated N-hydroxy-L-tert-leucinol-derived oxazoline N-oxides leading to a-acyloxy oxazolines and, after methanolysis, to the target molecules in 67-80% yield and 94-98% ee.
