769104-79-2Relevant academic research and scientific papers
SAR study of 1-aryl-4-(phenylarylmethyl)piperazines as ligands for both dopamine D2 and serotonin 5-HT1A receptors showing varying degrees of (Ant)agonism. Selection of a potential atypical antipsychotic
Feenstra, Roelof Willem,Van Den Hoogenband, Adri,Stroomer, Cornelis Nicolaas Jozef,Van Stuivenberg, Herman Heinrich,Tulp, Martin Theodorus Maria,Long, Stephen Kenneth,Van Der Heyden, Johannes Antonius Maria,Kruse, Cornelis Gerrit
, p. 1326 - 1330 (2006)
The syntheses of several 1-aryl-4-(arylpyridylmethyl)piperazines (4) and their affinities for dopamine D2 and serotonin 5-HT1A receptors are described. The compounds were evaluated both in vitro and in vivo, resulting in the identification of the drug candidate SLV313 (4e) with equipotent and full D2 receptor antagonism and 5-HT1A receptor agonism. Minor structural modifications in SLV313 revealed the possibility of designing compounds possessing varying degrees of partial agonism on one or both target receptors.
