76911-22-3Relevant academic research and scientific papers
Preparation method of tazobactam
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Paragraph 0019; 0027; 0030-0031, (2019/04/30)
The invention discloses a preparation method of tazobactam. The method includes the steps that 6 alpha-bromine penicillium alkane-3 alpha-carboxylate-1 beta-oxide is used as a raw material, and the tazobactam is obtained through the steps of esterification, reduction, thermal cracking, chloromethylation, azidation, bi-oxidization, cyclization addition and deprotection. According to the method, benzyl bromide is adopted as a protecting group of a carboxylic acid group in an esterification reaction in the presence of sodium bicarbonate, and then benzyl protection is removed through a hydrogenolysis reaction. Compared with an existing process route, the carboxyl protection and removal method has the advantages that the process is simple, environmental friendliness is achieved, and byproductsare fewer.
