769115-54-0Relevant academic research and scientific papers
Discovery of a series of acrylic acids and their derivatives as chemical leads for selective EP3 receptor antagonists
Asada, Masaki,Obitsu, Tetsuo,Nagase, Toshihiko,Sugimoto, Isamu,Yamaura, Yoshiyuki,Sato, Kazutoyo,Narita, Masami,Ohuchida, Shuichi,Nakai, Hisao,Toda, Masaaki
experimental part, p. 6567 - 6582 (2009/12/09)
A series of acrylic acids and their structurally related compounds were evaluated for their binding affinity to four EP receptor subtypes (EP1-4). Starting from the initial hit 3, which was discovered in our in-house library, compounds 4 and 5 were identified as new chemical leads as candidates for further optimization towards a selective EP3 receptor antagonist. The identification process of these compounds and their pharmacokinetic profiles are presented.
