769121-77-9Relevant academic research and scientific papers
Kinetic Resolution of 2-Substituted 1,2-Dihydroquinolines by Rhodium-Catalyzed Asymmetric Hydroarylation?
Cai, Baohua,Meng, Ling,Wang, Jun Joelle,Yang, Qingjing
, p. 1606 - 1610 (2021)
A highly efficient kinetic resolution of racemic 2-substituted 1,2-dihydroquinolines via Rh-catalyzed asymmetric hydroarylation has been described for the first time. A variety of arylboronic acids coupled with 2-substituted 1,2-dihydroquinolines under mild reaction condition. The transformations into the enantio-enriched 2,3-diaryl-tetrahydroquinolines as well as the recovered chiral 2-aryl-dihydroquinolines were obtained with high yields and excellent enantioselectivities (86%—99% ee, s factor up to 1057).
Enantioselective nucleophilic addition of organometallic reagents to quinoline: Regio-, stereo- and enantioselectivity
Amiot, Franck,Cointeaux, Laure,Jan Silve, Emmanuelle,Alexakis, Alexandre
, p. 8221 - 8231 (2007/10/03)
Some 2-alkyl-1,2-dihydroquinoline and some 2-aryl-1,2-dihydroquinoline were obtained by enantioselective addition of methyl-, butyl-, phenyl- and 1-naphthyllithium on quinoline. Bisoxazolines were used as external chiral ligands, giving enantiomeric exces
