769174-40-5Relevant academic research and scientific papers
α-Cycloalkyl-substituted ω-keto-dicarboxylic acids as lipid regulating agents
Bell, Roel P.L.,Verdijk, Dennis,Relou, Mike,Smith, Dennis,Regeling, Henk,Ebbers, Eelco J.,C. Leemhuis, Frank M.,Oniciu, Daniela C.,Cramer, Clay T.,Goetz, Brian,Pape, Michael E.,Krause, Brian R.,Dasseux, Jean-Louis
, p. 223 - 236 (2007/10/03)
A series of cycloalkyl-substituted oxo-alkanedicarboxylic acids have been prepared by the TosMIC methodology departing from haloalkyl-substituted cycloalkylcarboxylic esters. cyclopropyl derivatives showed IC50 activity in the 0.3-1.0 μM range
KETONE COMPOUNDS AND COMPOSITIONS FOR CHOLESTEROL MANAGEMENT AND RELATED USES
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Page/Page column 226; 234, (2010/02/13)
The present invention relates to novel ketone compounds, compositions comprising ketone compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias, dysproteinemias, and glucose metabolism disorders comprising administering a composition comprising a ketone compound. The compounds, compositions, and methods of the invention are also useful for treating and preventing Alzheimer's disease, Syndrome X, peroxisome proliferator activated receptor-related disorders, septicemia, thrombotic disorders, obesity, pancreatitis, hypertension, renal disease, cancer, inflammation, and impotence. In certain embodiments, the compounds, compositions, and methods of the invention are useful in combination therapy with other therapeutics, such as hypocholesterolemic and hypoglycemic agents.
