76927-60-1Relevant academic research and scientific papers
Process for production of chenodeoxycholic acid
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, (2008/06/13)
A process for producing chenodeoxycholic acid of the following formula STR1 which comprises reducing a 12-oxocholanic acid tosylhydrazone compound of the following formula STR2 wherein R1 and R2 are identical or different and each re
Potential Bile Acid Metabolites. 6. Stereoisomeric 3,7-Dihydroxy-5β-cholanic Acids
Iida, Takashi,Chang, Frederic C.
, p. 2966 - 2972 (2007/10/02)
New synthetic routes to the four possible 3,7-dihydroxy acids are described.The principal reactions involved were inversions with DMF and Me2SO-crown ether and reduction of 12-oxo tosylhydrazones.Inversion of 3α-tosylates by the Me2SO-crown ether method succeeded but that of the corresponding mesylates did not.A table of 1H NMR chemical shift reference data of monosubstituted methyl cholanates pertinent to bile acid characterization has been expanded.
