76932-60-0

Basic information

• Product Name: Nafarelin acetate
• Synonyms: Nafarelin acetate(76932-56-4 free base);Luteinizing hormone-releasing factor (pig), 6-[3-(2-naphthalenyl)-D-alanine]-, acetate (salt)
• CAS NO: 76932-60-0
• Molecular Formula: C66H83N17O13.C2H4O2
• Molecular Weight: 1382.54
• Mol File: 76932-60-0.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Nafarelin acetate(CAS DataBase Reference)
• NIST Chemistry Reference: Nafarelin acetate(76932-60-0)
• EPA Substance Registry System: Nafarelin acetate(76932-60-0)

Safety Data

• Hazardous Substances Data: 76932-60-0(Hazardous Substances Data)

Usage

Description

Nafarelin is an agonist of gonadotropin-releasing hormone (GNRH). It is a long-acting agent that, after an initial increase in sex hormone levels, decreases the level of circulating gonadotropins and sex hormones. In vivo, nafarelin (0.5-2.0 μg/kg, s.c.) reduces plasma levels of luteinizing hormone and testosterone (Item Nos. 15645 | ISO60154) as well as testicular volume, sperm count, sperm motility, and duration of ejaculation in male dogs. Nafarelin (32 μg/animal per day) inhibits estrus in female beagle dogs. It also reduces the volume of endometrial tissue in a rat model of endometriosis. Formulations containing nafarelin have been used in the treatment of endometriosis and central precocious puberty.