76939-46-3

Basic information

• Product Name: 8-BROMOADENOSINE-3',5'-CYCLIC MONOPHOSPHATE SODIUM SALT
• Synonyms: 8-bromoadenosine-3’,5’-cyclicmonophosphate(8-br-camp),sodiumsalt;CAMP, 8-BR, NA;ADENOSINE 3',5'-CYCLIC MONOPHOSPHATE, 8-BROMO-, SODIUM SALT;8-BROMOADENOSINE 3':5'-CYCLIC MONOPHOSPHATE SODIUM SALT;8-BROMOADENOSINE-3',5'-CYCLIC MONOPHOSPHATE SODIUM SALT;8-BROMOADENOSINE-3',5'-CYCLOPHOSPHATE SODIUM SALT;8-BROMO-CAMP, NA;8-BROMO-CAMP, SODIUM SALT
• CAS NO: 76939-46-3
• Molecular Formula: C10H10BrN5NaO6P
• Molecular Weight: 430.08
• Product Categories: Cyclic Nucleotide related
• Mol File: 76939-46-3.mol
• Article Data: 0

Chemical Properties

• Appearance: off-white/powder
• Storage Temp.: −20°C
• Solubility: H2O: 100 mg/mL
• Stability: Hygroscopic, Moisture Sensitive
• BRN: 7739743
• CAS DataBase Reference: 8-BROMOADENOSINE-3',5'-CYCLIC MONOPHOSPHATE SODIUM SALT(CAS DataBase Reference)
• NIST Chemistry Reference: 8-BROMOADENOSINE-3',5'-CYCLIC MONOPHOSPHATE SODIUM SALT(76939-46-3)
• EPA Substance Registry System: 8-BROMOADENOSINE-3',5'-CYCLIC MONOPHOSPHATE SODIUM SALT(76939-46-3)

Safety Data

• Safety Statements: 22-24/25
• WGK Germany: 3
• F: 10-21
• Hazardous Substances Data: 76939-46-3(Hazardous Substances Data)

Usage

Chemical Properties

Off-white powder

Uses

8-Bromoadenosine 3′,5′-cyclic monophosphate sodium salt has been used:to study its effect on fas and caspase-3 mRNA expression and on P4 production in bovine mid luteal cell cultureused to treat choriocarcinoma BeWo cell line and study its effect on cell viability, apoptosis and morphological changes in the nucleiin superfusion medium for head kidneys stimulation

General Description

8-Bromoadenosine 3′:5′-cyclic monophosphate is a brominated cyclic mononucleotide.

Biological Activity

Cell-permeable cAMP analog; activator of protein kinase A. Also available as part of the PKA Tocriset? .

Biochem/physiol Actions

Cell-permeable cAMP analog having greater resistance to hydrolysis by phosphodiesterases than cAMP. Activates protein kinase A, inhibits growth, decreases proliferation, increases differentiation, and induces apoptosis of cultured cells.