7694-50-0Relevant articles and documents
Reactions of sulfur- and phosphorus-substituted fluoroalkylating silicon reagents with imines and enamines under acidic conditions
Kosobokov, Mikhail D.,Dilman, Alexander D.,Struchkova, Marina I.,Belyakov, Pavel A.,Hu, Jinbo
supporting information; experimental part, p. 2080 - 2086 (2012/04/23)
Nucleophilic fluoroalkylation reactions of imines and enamines with α-phenylthio, α-phenylsulfonyl, and α-diethylphosphoryl substituted fluorinated silanes have been investigated. The reactions are promoted by hydrofluoric acid generated in situ from pota
Preparation of tertiary alkyl carbinamines, propargylamines, and α-heteroarylamines by ketone-based aminoalkylation
Katritzky, Alan R.,Yang, Hongfang,Singh, Sandeep K.
, p. 286 - 290 (2007/10/03)
(Chemical Equation Presented). Ketones 6a-i were converted into their benzotriazolylamine adducts 8a-i either directly from the corresponding ketone 6a or via enamines 7b-i. Adducts 8a-i on treatment with Grignard reagents, lithium phenylacetylide, or heteroaryllithiums gave tertiary alkyl carbinamines 9a-h (47-61%), propargylamines 10a-i (30-98%), and α-heteroarylamines 11a-k (44-85%), respectively.
Optimum Conditions for Enamine Synthesis by an Improved Titanium Tetrachloride Procedure
Carlson, Rolf,Nilsson, Asa,Stroemqvist, Mats
, p. 7 - 14 (2007/10/02)
A modified procedure for enamine synthesis which results in shorter times and increased yield has been developed.Optimum conditions for the synthesis have been obtained from a series of eight different acyclic ketones with three different amines.The optimum conditions were determined either by response surface methodologgy or by simplex technique.In view of the results some consideration of the mechanism is briefly discussed.
