7696-84-6Relevant academic research and scientific papers
Iminium ion catalysis: Use of the α-effect in the acceleration of the Diels-Alder reaction
Cavill, Julie L.,Peters, Jens-Uwe,Tomkinson, Nicholas C. O.
, p. 728 - 729 (2003)
The α-effect can be used in the acceleration of the DielsAlder reaction between a series of dienes and electron deficient dienophiles using iminium ion catalysis, providing a novel molecular scaffold capable of performing this class of catalytic process.
Synthesis of N′-propylhydrazide analogs of hydroxamic inhibitors of histone deacetylases (HDACs) and evaluation of their impact on activities of HDACs and replication of hepatitis C virus (HCV)
Kozlov, Maxim V.,Konduktorov, Konstantin A.,Shcherbakova, Anastasia S.,Kochetkov, Sergey N.
supporting information, p. 2369 - 2374 (2019/06/17)
N′-Propylhydrazide analogs of hydroxamic inhibitors of histone deacetylases (HDACs), including tubastatin A, vorinostat and belinostat, were synthesized. All prepared compounds inhibited HDAC1/2/3, but not HDAC6, except for one hydrazide analog of HDAC4/5/7 inhibitor that was completely inactive. A novel 4-substituted derivative of N′-propylbenzohydrazide with extremely high anti-HCV activity was discovered.
