76960-79-7

Upstream product

• 588-72-7 [(E)-2-bromoethenyl]benzene 
• 625-38-7 but-3-enoic acid 
• 536-74-3 phenylacetylene 
• 195379-25-0 (3E,5E)-6-Phenyl-hexa-3,5-dienoic acid amide 
• 66680-87-3 (E)-1-phenyl-(2-tributylstannyl)ethene 
• 190203-25-9 (E)-4-iodobut-3-en-1-oic acid 
• 540803-87-0 6-phenylhex-5-ynoic acid 
• 14371-10-9 (E)-3-phenylpropenal 
• 51114-94-4 (2-carboxyethyl)triphenylphosphonium bromide 
• 73737-55-0 (E)-4-phenylbut-3-enal 

Downstream Products

• 79994-37-9 Methyl (E,E)-6-phenylhexa-3,5-dienoate 
• 1234862-84-0 (3E,5E)-1,6-diphenylhexa-3,5-dien-1-one 

Relevant academic research and scientific papers

Direct Enantioselective and Regioselective Alkylation of β,γ-Unsaturated Carboxylic Acids with Chiral Lithium Amides as Traceless Auxiliaries

Efficient asymmetric alkylation of β,γ-unsaturated carboxylic acids without prior functionalization is enabled by chiral lithium amides. Enantioselectivity is imparted by a putative mixed lithium amide-enediolate aggregate that acts a traceless auxiliary formed in situ, allowing for a direct asymmetric alkylation and a simple recovery of the chiral reagent.

Rhodium(II)-catalyzed stereoselective synthesis of allylsilanes

The rhodium-catalyzed decomposition of 2-(triisopropylsilyl)ethyl aryl- and vinyldiazoacetates results in the stereoselective formation of Z-allylsilanes. The transformation is considered to proceed by silyl-directed intramolecular C-H functionalization to form a β-lactone intermediate followed by a silyl-activated extrusion of carbon dioxide.

Suppression of β-hydride elimination in the intramolecular hydrocarboxylation of alkynes leading to the formation of lactones

Palladium-catalyzed intramolecular cyclization of the alkynoic acids was studied which gave the five- and six-membered lactones in moderate yields. The reaction can be conducted simply by heating a toluene solution of alkynoic acids at 100 °C in the prese

Stereoselective access to functionalized β-γ unsaturated acids

Stereoselective synthesis of vinylstannanes bearing a carboxylic acid function was achieved from β-γ alkynoic acids via hydrostannation, stannylcupration or silastannation reactions. Regioselectivity is highly dependent on the nature of the stannylanions used and on protection of the carboxylic acid function.

Histone deacetylase inhibitors

Histone deacetylase is a metallo-enzyme with zinc at the active site. Compounds having a zinc-binding moiety, such as, for example, a carboxylic acid group, can inhibit histone deacetylase. Histone deacetylase inhibition can repress gene expression, inclu

Pivotal role of (E)-3-carbamoyl-1-propenylboronic acid in the combination of Suzuki-Miyaura coupling and enzyme reactions: Synthesis of (3E,5E)-and (3E,5Z)-6-phenyl-3,5-hexadienoic acid

The first example of the enzyme-catalyzed hydrolysis of a nitrile bearing alkenylboronic acid functionality and its application to the synthesis of dienecarboxylic acids are described. (E)-3-Carbamoyl-1-propenylboronic acid was obtained by an incubation o

TRANSITION METAL-CATALYZED SYNTHESES OF ORGANIC ACIDS BY CHELATION-PROMOTED REGIOSELECTIVE DOUBLE BOND INSERTION

The rhodium- or nickel-catalyzed reaction of vinylic halides with alkali salts of 3-butenoic acids leads to regioselective formation of dienoic acids, containing 3,5-conjugated double bonds.Monoarylacetylenes also react with 3-butenoic acids in a rhodium-