76960-79-7Relevant articles and documents
Direct Enantioselective and Regioselective Alkylation of β,γ-Unsaturated Carboxylic Acids with Chiral Lithium Amides as Traceless Auxiliaries
Yu, Kai,Miao, Bukeyan,Wang, Wenqi,Zakarian, Armen
supporting information, (2019/03/19)
Efficient asymmetric alkylation of β,γ-unsaturated carboxylic acids without prior functionalization is enabled by chiral lithium amides. Enantioselectivity is imparted by a putative mixed lithium amide-enediolate aggregate that acts a traceless auxiliary formed in situ, allowing for a direct asymmetric alkylation and a simple recovery of the chiral reagent.
Suppression of β-hydride elimination in the intramolecular hydrocarboxylation of alkynes leading to the formation of lactones
Huo, Zhibao,Patil, Nitin T.,Jin, Tienan,Pahadi, Nirmal K.,Yamamoto, Yoshinori
, p. 680 - 684 (2008/02/09)
Palladium-catalyzed intramolecular cyclization of the alkynoic acids was studied which gave the five- and six-membered lactones in moderate yields. The reaction can be conducted simply by heating a toluene solution of alkynoic acids at 100 °C in the prese
Histone deacetylase inhibitors
-
, (2008/06/13)
Histone deacetylase is a metallo-enzyme with zinc at the active site. Compounds having a zinc-binding moiety, such as, for example, a carboxylic acid group, can inhibit histone deacetylase. Histone deacetylase inhibition can repress gene expression, inclu
