76985-08-5

Basic information

• Product Name: 2-AMINO-3-BIPHENYL-4-YL-PROPIONIC ACID
• Synonyms: (RS)-2-AMINO-3-(4-BIPHENYL)PROPIONIC ACID;DL-BIPHENYLALANINE;2-AMINO-3-BIPHENYL-4-YL-PROPIONIC ACID;4-Phenyl-DL-Phenylalanine;DL-4-Phenyl-Phe-OH;alpha-Amino-(1,1'-biphenyl)-4-propanoic acid;2-AMino-3-(4-biphenylyl)propanoic Acid;DL-4-Phenyl-Phe-OH 4-Phenyl-DL-Phenylalanine
• CAS NO: 76985-08-5
• Molecular Formula: C₁₅H₁₅NO₂
• Molecular Weight: 241.29
• Mol File: 76985-08-5.mol

Chemical Properties

• Boiling Point: 428.6 °C at 760 mmHg
• Flash Point: 213 °C
• Appearance: white crystalline powder
• Density: 1.19 g/cm³
• Vapor Pressure: 4.15E-08mmHg at 25°C
• Refractive Index: 1.607
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• CAS DataBase Reference: 2-AMINO-3-BIPHENYL-4-YL-PROPIONIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-3-BIPHENYL-4-YL-PROPIONIC ACID(76985-08-5)
• EPA Substance Registry System: 2-AMINO-3-BIPHENYL-4-YL-PROPIONIC ACID(76985-08-5)

Safety Data

• Hazardous Substances Data: 76985-08-5(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-Amino-3-biphenyl-4-yl-propionic acid is utilized as a key intermediate in the synthesis of various pharmaceuticals for its ability to be incorporated into complex molecular structures, enhancing the therapeutic potential of the resulting compounds.
Used in Medicinal Chemistry Research:
In the realm of medicinal chemistry, 2-Amino-3-biphenyl-4-yl-propionic acid is employed as a structural component in the design and development of new drugs, leveraging its unique properties to improve the efficacy and selectivity of pharmaceutical agents.
Used in Organic Synthesis:
2-Amino-3-biphenyl-4-yl-propionic acid is used as a versatile building block in organic synthesis, allowing for the creation of a wide array of organic compounds with diverse applications across various industries.

InChI:InChI=1/C15H15NO2/c16-14(15(17)18)10-11-6-8-13(9-7-11)12-4-2-1-3-5-12/h1-9,14H,10,16H2,(H,17,18)

Upstream product

• 2567-29-5 p-phenylbenzyl bromide 
• 1122-91-4 4-bromo-benzaldehyde 
• 98-80-6 phenylboronic acid 
• 3218-36-8 4-Phenylbenzaldehyde 
• 38913-04-1 ethyl 3-([1,1'-biphenyl]-4-yl)-2-cyanoacrylate 

Downstream Products

• 155760-02-4 (S)-3-([1,1'-biphenyl]-4-yl)-2-aminopropanoic acid 
• 170080-13-4 ([1,1’-biphenyl]-4-yl)alanine 
• 13026-23-8 (2E)-3-(1,1'-biphenyl-4-yl)acrylic acid 
• 515158-71-1 methyl 3-([1,1‘-biphenyl]-4-yl)-2-aminopropanoate 

Relevant articles and documents

Preparation method for 2-amino-3-biphenylpropionic acid

The invention discloses a preparation method for 2-amino-3-biphenylpropionic acid. The preparation method comprises the following steps: step 1, with p-bromobenzaldehyde and phenylboronic acid as rawmaterials and an organic solvent as a reaction solvent, subjecting the p-bromobenzaldehyde and the phenylboronic acid to a reaction under the actions of alkali and a catalyst so as to obtain biphenylcarbaldehyde (II); step 2, allowing the biphenylcarbaldehyde (II) to react with ethyl cyanoacetate under the action of the alkali so as to obtain an intermediate (III); step 3, allowing the intermediate (III) to generate a reduction reaction with hydrogen under the catalytic action of Pd/C in a hydrogen atmosphere so as to obtain an intermediate (IV); step 4, allowing the intermediate (IV) to be hydrolyzed into an amide compound (V) in absolute ethyl alcohol under the action of the alkali; and step 5, subjecting the amide compound (V) to a reaction under the actions of bromine and sodium hydroxide so as to obtain the 2-amino-3-biphenylpropionic acid. The preparation method provided by the invention has the advantages of cheap and easily-available raw materials, low production cost, short reaction steps, mild reaction conditions, convenient post-treatment, high yield and applicability to industrial production.