76991-05-4 Usage
Uses
N20C is a non-competitive NMDA receptor open-channel blocker.
Biological Activity
Selective, non-competitive NMDA receptor antagonist (IC 50 = 5 μ M); binds to the receptor-associated ion channel and prevents glutamate-induced Ca 2+ influx. In vivo, displays neuroprotective activity and is reported to be brain-penetrant.
Check Digit Verification of cas no
The CAS Registry Mumber 76991-05-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,6,9,9 and 1 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 76991-05:
(7*7)+(6*6)+(5*9)+(4*9)+(3*1)+(2*0)+(1*5)=174
174 % 10 = 4
So 76991-05-4 is a valid CAS Registry Number.
InChI:InChI=1/C17H20N2O.ClH/c18-17(20)13-19-12-11-16(14-7-3-1-4-8-14)15-9-5-2-6-10-15;/h1-10,16,19H,11-13H2,(H2,18,20);1H
76991-05-4Relevant articles and documents
A novel N-methyl-D-aspartate receptor open channel blocker with in vivo neuroprotectant activity
Planells-Cases, Rosa,Montoliu, Carmina,Humet, Marc,Fernandez, Asia M.,Garcia-Martinez, Carolina,Valera, Elvira,Merino, Jaime M,Perez-Paya, Enrique,Messeguer, Angel,Felipo, Vicente,Ferrer-Montiel, Antonio
, p. 163 - 173 (2002)
Excitotoxicity has been implicated in the etiology of ischemic stroke, chronic neurodegenerative disorders, and very recently, in glioma growth. Thus, the development of novel neuroprotectant molecules that reduce excitotoxic brain damage is vigorously pu