76994-77-9

Upstream product

• 55656-88-7 di-n-butylthioxophosphoranyl bromide 
• 69471-51-8 2',3',5'-tri-O-acetyl-N²-tritylguanosine 
• 76994-75-7 2',3',5'-tri-O-acetyl-O⁶-dibutylposphinothioyl-N²-tritylguanosine 
• 69471-51-8 2',3',5'-Tri-O-acetyl-N²-tritylguanosine 
• 76994-75-7 Acetic acid (3R,4R,5R)-4-acetoxy-5-acetoxymethyl-2-[6-(dibutyl-phosphinothioyloxy)-2-(trityl-amino)-purin-9-yl]-tetrahydro-furan-3-yl ester 

Relevant academic research and scientific papers

Synthesis and Properties of O6-Substituted Guanosine Derivatives

Reactions of 2',3',5'-tri-O-acetyl-N2-protected or unprotected guanosine derivatives with phosphoryl, phosphinothioyl, arylsulfonyl, and silyl halides in dichloromethane gave the corresponding O6-substituted guanosine derivatives in good yields.In these reactions, 4-(dimethylamino)pyridine (DMAP) was found to be very effective catalyst.The physical data of these products and their stabilities under acidic and basic conditions were described in detail.Selective detritylation of O6-arylsulfonyl-N2-tritylguanosinde derivatives was accomplished by treatment with 80percent aceti c acid.It was found that O6-dibutylphosphinothioyl derivatives were relatively stable under conditions where acetyl group was predominantly removed.

NEW GUANOSINE DERIVATIVES: FACILE O6-PHOSPHORYLATION, THIOPHOSPHINYLATION, SULPHONYLATION AND SILYLATION OF GUANOSINE DERIVATIVES BY 4-DIMETHYLAMINOPYRIDINE CATALIZED REACTION

Appropriately protected guanosine derivatives were successfully converted to the corresponding O6-substituted guanosine derivatives by treatment with dialkyl- or diaryl-phosphoryl halides, dialkyl- or diaryl-phosphinothioyl halides, arenesulfon