76996-16-2

Usage

Uses

Used in Pharmaceutical Research:
2-Amino-4-bromo-6-methylbenzothiazole is used as a key intermediate in the synthesis of drug molecules for various therapeutic applications. Its unique structure and properties make it a promising candidate for the development of new medications.
Used in Organic Synthesis:
2-Amino-4-bromo-6-methylbenzothiazole serves as a valuable building block in the creation of complex organic molecules, contributing to the advancement of chemical research and the discovery of novel materials.
Used as an Antimicrobial Agent:
2-Amino-4-bromo-6-methylbenzothiazole is used as an antimicrobial agent, demonstrating potential activity against various types of bacteria and other microorganisms, which can be beneficial in the development of new antibiotics.
Used as an Anticancer Agent:
It is used as an anticancer agent, with studies indicating its potential to target and inhibit the growth of cancer cells, offering a new avenue for cancer treatment research.
Used as an Antiviral Agent:
2-Amino-4-bromo-6-methylbenzothiazole is used as an antiviral agent, showing promise in inhibiting the replication and spread of viruses, which could lead to the development of new antiviral therapies.
Used in Fluorescence-based Sensors and Imaging Agents:
Due to its fluorescent properties, 2-Amino-4-bromo-6-methylbenzothiazole is used in the development of fluorescence-based sensors and imaging agents, which can be applied in various fields such as diagnostics, bioimaging, and environmental monitoring.
It is important to handle 2-Amino-4-bromo-6-methylbenzothiazole with caution, as it may pose hazards upon exposure, and should only be used by trained professionals in a controlled laboratory environment.

InChI:InChI=1/C8H7BrN2S/c1-4-2-5(9)7-6(3-4)12-8(10)11-7/h2-3H,1H3,(H2,10,11)

Upstream product

• 583-68-6 2-bromo-p-toluidine 
• 540-72-7 sodium thiocyanide 
• 2536-91-6 6-methylbenzothiazol-2-ylamine 
• 622-52-6 p-methylphenylthiourea 
• 106-49-0 p-toluidine 
• 103-89-9 4-Methylacetanilide 
• 614-83-5 2-bromo-4-methylacetanilide 

Downstream Products

• 155596-87-5 2,4-dibromo-6-methylbenzothiazole 
• 1401515-11-4 C₁₀H₁₀BrN₃OS 
• 1329673-02-0 2-bromo-4-(3-chloro-4-fluorophenyl)-6-methylbenzo[d]thiazole 
• 1329671-49-9 4-(3-chloro-4-fluorophenyl)-N-(1-(2-chloropyridin-4-yl)piperidin-4-yl)-6-methylbenzo[d]thiazol-2-amine 
• 1329673-01-9 4-(3-chloro-4-fluorophenyl)-6-methylbenzo[d]thiazol-2-amine 
• 665004-79-5 dibenzyl-(4-bromo-6-methyl-benzothiazol-2-yl)-amine 

Relevant academic research and scientific papers

Novel synthesis and antimicrobial activity of 3-substituted 5-bromo-7-methyl-1,2,4-triazolo-[3,4-b]-benzothiazoles

4-Methyl acetanilide (1) on treatment with bromine in acetic acid, followed by hydrolysis with dilute HCl/NaOH solution, yielded 2-bromo-4-methyl aniline (2), which on treatment with sodium thiocyanate in acetic acid afforded 2-amino-4-bromo-6-methyl benzothiazole (3). Compound 3 in ethylene glycol was heated at 150°C with 80% hydrazine hydrate to get 4-bromo-2-hydrazino-6- methyl benzothiazole (4). This hydrazino compound 4 on heating with formic acid for 3 h yielded 4-bromo-2-hydrazinoformyl-6-methyl benzothiazole (5). Same compound 4 when heated independently with formic acid for 6 h/urea for 3 h/carbon disulfide in alkali afforded 5-bromo-7-methyl (6)/5-bromo-3-hydroxy-7- methyl (7)/5-bromo-3-mercapto-7-methyl (8)-1,2,4-triazolo-[3,4-b]- benzothiazoles, respectively. Compound 4 on heating with acetic acid/acetic anhydride gave acetyl benzothiazolyl derivative 9, which on cyclization with orthophosphoric acid yielded 5-bromo-3,7-dimethyl-1,2,4-triazolo-[3,4-b]- benzothiazole (10). All these newly synthesized compounds were screened for antimicrobial activity against Escherichia coli (Gram -ve), Bacillus subtilis (Gram +ve), Erwinia carotovora, and Xanthomonas citri using ampicillin, streptomycin, and penicillin as a standard for comparison.

SUBSTITUTED BENZOAZOLE PDE4 INHIBITORS FOR TREATING PULMONARY AND CARDIOVASCULAR DISORDERS

The invention relates to substituted benzothiazoles, benzoxazoles—and their counterparts having pyridine and pyrimidine rings replacing the benzene ring—that are PDE4 inhibitors useful for treating stroke, myocardial infarct, and cardiovascular inflammatory conditions, to pharmaceutical compositions comprising these compounds, and to methods for the treatment of stroke, myocardial infarct, and cardiovascular inflammatory conditions in a mammal. The compounds have general formula I: in which A and B are carbocycles or heterocycles. A particular embodiment is

The fungicidal benzothiazole methoxyacrylates: Synthesis, conformational analysis and fungicidal activity

Synthesis of a series of novel benzothiazole methoxyacrylate compounds (3-4) based on the antifungal natural product, Strobilurin A is described. Fungicidal activities of 3-4 against six representative fungal diseases and their comparative conformational analyses vs Strobilurin A are accounted.

Benzothiazole derivatives and methods of use

The present invention relates to a novel benzothiazole derivative of the following general formula (I) or its (E) , (Z)isomer, and processes for preparation thereof, STR1 in which R1, R2 and R3 independently of one another represent hydrogen, halogen, straight and branched (C1 -C8)alkyl, (C1 -C8)halogenoalkyl or (C1 -C8)alkoxy, X represents N or CH, Y represents a group -OR4, SR5 or STR2 R4, R5, R6 and R7 independently of one another represent hydrogen, straight and branched (C1 -C16)alkyl, (C3 -C8)alkenyl, (C3 -C8)alkynyl, (C3 -C8)cycloalkyl, alkyl substituted with (C1 -C6)alkoxy or (C1 -C6)halogenoalkyl, or represent a substituted phenyl, phenylacyl or benzyl group wherein the possible substituent on the phenyl, phenylacyl or benzyl group includes halogen, straight and branched (C1 -C8)alkyl, (C1 -C8)alkoxy, (C3 -C8)alkenyl, (C3 -C8)alkynyl, phenoxy, nitro, cyano and a five- or six-membered heterocyclic group containing one to four nitrogen atoms. The compound of formula (I) is useful for combating phythopathogenic organisms and fungi present on animal.

Novel benzothiazole derivatives and processes for preparing the same

The present invention relates to a novel benzothiazole derivative of the following general formula (I) or its (E), (Z)-isomer, and processes for preparation thereof, in which R1, R2 and R3independently of one another represent hydrogen, halogen, straight and branched (C1-C8)alkyl, (C1-C8) halogenoalkyl or (C1-C8)alkoxy, Xrepresents N or CH, Yrepresents a group -OR4, -SR5 or R4, R5, R6 and R7independently of one another represent hydrogen, straight and branched (C1-C16)alkyl, (C3-C8)alkenyl, (C3-C8)alkynyl, (C3-C8)cycloalkyl, alkyl substituted with (C1-C6)alkoxy or (C1-C6)halogenoalkyl, or represent a substituted phenyl, phenylacyl or benzyl group wherein the possible substituent on the phenyl, phenylacyl or benzyl group includes halogen, straight and branched (C1-C8)alkyl, (C1-C8)alkoxy, (C3-C8)alkenyl, (C3-C8)alkynyl, phenoxy, nitro, cyano and a five- or six-membered heterocyclic group containing one to four nitrogen atoms. The compound of formula (I) is useful for combating phythopathogenic organisms and fungi present on animal.