769964-71-8

Upstream product

• 98482-70-3 (S)-4-oxo-3-{[(phenylmethoxy)carbonyl]amino}butanoic acid 1,1-dimethylethyl ester 
• 146398-02-9 tert-butyl (S)-3-benzyloxycarbonylamino-4-hydroxybutyrate 
• 5545-52-8 Z-D(tBu)-OH 
• 819076-55-6 3-benzyloxycarbonylamino-4-(5-fluoro-2,3-dihydro-indol-1-yl)-butyric acid tert-butyl ester 
• 88319-44-2 2S-2-benzyloxycarbonylamino-2-t-butylmethyl-acetic acid 

Downstream Products

• 769964-73-0 (S)-4-(5-Fluoro-2,3-dihydro-indol-1-yl)-3-[(S)-2-(3-methoxy-benzoylamino)-4,4-dimethyl-pentanoylamino]-butyric acid tert-butyl ester 
• 769965-30-2 (S)-4-(5-Fluoro-2,3-dihydro-indol-1-yl)-3-[(S)-2-(3-methoxy-benzoylamino)-4,4-dimethyl-pentanoylamino]-butyric acid 

Relevant academic research and scientific papers

Arylaminoethyl amides as noncovalent inhibitors of cathepsin S. Part 2: Optimization of P1 and N-aryl

A systematic study of anilines led to the discovery of a metabolically robust fluoroindoline replacement for the alkoxy aniline toxicophore in 1. Investigations of the P1 pocket resulted in the discovery of a wide tolerance of functionality leading to the discovery of 11 as a potent and selective inhibitor of cathepsin S.