769966-12-3Relevant academic research and scientific papers
Synthesis and SAR of arylaminoethyl amides as noncovalent inhibitors of cathepsin S: P3 cyclic ethers
Tully, David C.,Liu, Hong,Chatterjee, Arnab K.,Alper, Phil B.,Epple, Robert,Williams, Jennifer A.,Roberts, Michael J.,Woodmansee, David H.,Masick, Brian T.,Tumanut, Christine,Li, Jun,Spraggon, Glen,Hornsby, Michael,Chang, Jonathan,Tuntland, Tove,Hollenbeck, Thomas,Gordon, Perry,Harris, Jennifer L.,Karanewsky, Donald S.
, p. 5112 - 5117 (2006)
The synthesis and structure-activity relationship of a series of arylaminoethyl amide cathepsin S inhibitors are reported. Optimization of P3 and P2 groups to improve overall physicochemical properties resulted in significant improvements in oral bioavail
