77006-52-1

Basic information

• Product Name: (4aR,8aR)-2,2-Dimethyl-3-phenyl-2,3,4a,5,6,7,8,8a-octahydro-benzo[4,5]imidazo[2,1-b]thiazol-3-ol; hydrochloride
• Synonyms: (4aR,8aR)-2,2-Dimethyl-3-phenyl-2,3,4a,5,6,7,8,8a-octahydro-benzo[4,5]imidazo[2,1-b]thiazol-3-ol; hydrochloride
• CAS NO: 77006-52-1
• Molecular Weight: 338.901
• Mol File: 77006-52-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (4aR,8aR)-2,2-Dimethyl-3-phenyl-2,3,4a,5,6,7,8,8a-octahydro-benzo[4,5]imidazo[2,1-b]thiazol-3-ol; hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: (4aR,8aR)-2,2-Dimethyl-3-phenyl-2,3,4a,5,6,7,8,8a-octahydro-benzo[4,5]imidazo[2,1-b]thiazol-3-ol; hydrochloride(77006-52-1)
• EPA Substance Registry System: (4aR,8aR)-2,2-Dimethyl-3-phenyl-2,3,4a,5,6,7,8,8a-octahydro-benzo[4,5]imidazo[2,1-b]thiazol-3-ol; hydrochloride(77006-52-1)

Safety Data

• Hazardous Substances Data: 77006-52-1(Hazardous Substances Data)

Upstream product

• 1121-22-8 trans-1,2-Diaminocyclohexane 
• 7473-99-6 α-chloroisobutyrophenone 
• 30086-64-7 trans-2-thiohexahydrobenzimidazole 

Relevant articles and documents

Effect of Structural Change on Acute Toxicity and Antiinflammatory Activity in a Series of Imidazothiazoles and Thiazolobenzimidazoles

The effect of structural change on the biological activity of a series of imidazothiazoles and thiazolobenzimidazoles is described.It was found that compounds with polar substituents at the 2 or 3 position of the ring system are less acutely toxic while maintaining antiinflammatory activity.Other structural changes, such as the incorporation of a gem-dimethyl substituent in the 6 position, increase acute toxicity and eliminate antiinflammatory activity.The compound with the best activity/toxicity ratio contains an alkyl sulfonyl substituent on the thiazole ring.The thiazolobenzimidazole analogues are more potent than the imidazole analogues.