77015-50-0

Upstream product

• 555-16-8 4-nitrobenzaldehdye 
• 487-26-3 Flavanone 
• 112098-42-7 3-[1-(4-Nitro-phenyl)-meth-(Z)-ylidene]-2-phenyl-chroman-4-one 

Downstream Products

• 109754-36-1 C₂₃H₁₇N₃O₄ 
• 112098-42-7 3-[1-(4-Nitro-phenyl)-meth-(Z)-ylidene]-2-phenyl-chroman-4-one 
• 119139-33-2 4''-nitro-3-α-hydroxybenzylflavone 

Relevant academic research and scientific papers

3-Arylideneflavanones. Part 2: Reaction with diazomethane

3-Arylideneflavanones 1-9 were treated with diazomethane. As a result, the following compounds were obtained: the 3-spiropyrazolines (structure A)-2'-phenylchromanone-3'-spiro-3,4-phenyl-1-pyrazoline (1a) and its 3''- and 4''-derivatives (2a-9a), the 4-spiropyrazolines (structure B) 2'-phenylchromanone-3'-spiro-4-1H-5-phenyl-2-pyrazoline (1b) and the 4''-cyano (7b) and 3''-nitro (8b) derivatives; and the methylation product (structure C) 3-(4-N,N-diethyl-amino-β-methylbenzylidene)flavanone (5c).

NMR spectral studies of several series of E-3-arylideneflavanones: Realisation of some steric and electronic interactions

H-2 of E-3-arylideneflavanones differing only in the β-phenyl group is found to experience a reverse substituent chemical shift (s.c.s.) effect.An unfavourable steric interaction between this proton and the ortho-protons of β-phenyl group has been related to this observation.An interesting feature in the 1H NMR spectra of the heterocyclic analogs 5a-c is the significant deshielding of H-2 and shielding of H-β in the case of 5a.Intramolecular hydrogen bond formation between H-2 and the furano oxygen of 5a is probably responsible for this observation.From a studyof the 1H and 13C NMR spectral features of 8a-e which differ only in the 4'-substituent, it may be concluded that a 4'-substituent can polarise the C3-C-β and C=O ?-bonds as well as the ?-system of ring-A.The results of dual substituent parameter analysis of s.c.s. values of C-3, C-β, C-4, C-8a and C-6 for the series 8 have also been presented.

Flavonoids. Part 6. The Kinetics and Mechanism of Base-catalysed Isomerisation of 3-Arylideneflavanones

Base-catalysed Z->E conversion of 3-arylideneflavanones provide a unique system suitable for kinetic studies by 1H n.m.r. spectroscopy.Isomerisation studies of 10 enones in pyridine showed that a first-order unimolecular reaction was taking place.The