77016-75-2Relevant academic research and scientific papers
A two-photon fluorescent probe for ratiometric visualization of hypochlorous acid in live cells and animals based on a selenide oxidation/elimination tandem reaction
Xie, Xilei,Wu, Tianhong,Wang, Xu,Li, Yong,Wang, Kaiye,Zhao, Zhiwen,Jiao, Xiaoyun,Tang, Bo
, p. 11965 - 11968 (2018/11/27)
Utilizing the oxidation/elimination tandem reaction of the α-phenylseleno carbonyl moiety, a two-photon fluorescent probe for ratiometric visualization of hypochlorous acid was developed. Its superior sensing performance and practical applications were well demonstrated.
Ratio two-photon and near-infrared HClO detection fluorescence probe as well as preparation and application thereof
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, (2019/01/08)
The invention relates to a ratio two-photon and near-infrared HClO detection fluorescence probe as well as preparation and application thereof and belongs to the technical fields of synthesis and detection. The structural formula of the fluorescence probe is as shown in the specification. The fluorescence probe is prepared by the following steps: 1, reacting 4-(diethylamino) salicylaldehyde with ethyl acetoacetate and piperidine; 2, enabling 4-diethylaminobenzaldehyde to participate in the reaction; and 3, enabling cyclohexene to participate in the reaction to obtain a compound, respectively reacting the compound with lithium diisopropylamide and phenylselenenyl bromide, thereby obtaining the fluorescence probe. The probe can be reacted with the HClO to produce olefinic bonds, wavelength red shift is caused by the enlarged conjugated structure, and the ratio fluorescence change of which the short wavelength fluorescence intensity is reduced and long wavelength fluorescence intensity isenhanced is formed. Therefore, the design of the probe based on the Sharpless alkene synthesis reaction can be used for detecting the HClO, and the probe is simple in structure and has the advantagesof being high in selectivity, high in sensitivity, fast in transient response and the like.
