77036-77-2Relevant academic research and scientific papers
Synthetic approaches to 3-substituted-5'-(N-pyridiniummethyl)-4',5'- dihydropsoralen
Jabin, Ivan,Heindel, Ned D.,Rapp, Roben D.,Laskin, Jeffrey D.
, p. 31 - 39 (2000)
New synthetic approaches to 3-substituted-5'-(N-pyridiniummethyl)-4',5'- dihydropsoralens are described. The novel pathways presented utilize appropriately substituted coumarins and 4',5'-dihydropsoralens. The compounds proposed represent potential therap
Amino-and mercurio-substituted 4′,5'-dihydropsoralens and therapeutical uses thereof
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, (2008/06/13)
5′-substituted, 4′,5′-dihydropsoralen compounds (5) bearing tertiary amines (and salts thereof), quaternary ammonium moieties or organomercurial moieties are described. Also described are 2-substituted mercurimethyl-2-3-dihydro-benzofurans of forumla (7): Also reported are versatile direct syntheses through a hitherto unknown compounds such as 3-R-4,8-dimethyl-4′,5′-dihydro-5′-bromomethylpsoralen or a 3-R-4,8-dimethyl-4′, 5′-dihydro-5′-iodomethylpsoralen to prepare a structurally diverse array of partially reduced psoralens and benzofurans. The presence of a permanent ammonium charge in these psoralens precludes membrane passage and the mono-unsaturation precludes the cross-linking of nuclear DNA, thereby minimizing the mutagenic/carcinogenic side effects long associated with psoralen-derived therapies. The presence of a mercury functionality provides a reactive cell-binding group on these psoralens with unique cytotoxicity without light activation and an enhancement of cytotoxicity activity upon light activation. The invention also relates to These partially reduced and quaternized psoralens, amino-substituted psoralens, and mercurio psoralens display impressive pharmacology against PAM 212 keratinocytes, a model cell line employed as a test system to indicate epidermal cytotoxicity and cancer. The compounds of the invention also have antimicrobicidal activity useful in pharmacologic agents for mammals (e.g. the treatment of tuberculosis) as well as in controlling the growth of microorganisms on substrates and in aqueous systems.
