77038-49-4Relevant academic research and scientific papers
TMSOTf-promoted addition of alkynes to aldehydes: A novel synthesis of chroman-4-ones
Ji, Yeon Park,Ullapu, Punna Reddy,Choo, Hyunah,Jae, Kyun Lee,Min, Sun-Joon,Ae, Nim Pae,Kim, Youseung,Baek, Du-Jong,Yong, Seo Cho
, p. 5461 - 5469 (2008)
A novel synthetic method to prepare chalcones 2 and chroman-4-ones 3 by TMSOTf-promoted addition of alkynes 1 to various aldehydes has been developed. The ratios of chalcones 2, chroman-4-ones 3 and hydrated products 4 varied depending upon the substituents R (nBu, phenyl, H and TMS) on the alkynes 1. We also describe the transformation of the chalcones 2 to the corresponding chroman-4-ones 3 under basic conditions. Wiley-VCH Verlag GmbH & Co. KGaA, 2008.
