77053-53-3

Upstream product

• 32857-62-8 4-Trifluoromethylphenylacetic acid 
• 156276-22-1 methyl 2-hydroxy-2-(4-(trifluoromethyl)phenyl)acetate 
• 135325-18-7 methyl 2-(4-(trifluoromethyl)phenyl)acetate 

Downstream Products

• 77053-67-9 (1R,2S)-1-(4-Trifluoromethyl-phenyl)-cyclopropane-1,2-dicarboxylic acid dimethyl ester 
• 460356-17-6 (Z)-3-Amino-7-methanesulfonyloxy-2-(4-trifluoromethyl-phenyl)-hept-2-enoic acid methyl ester 
• 1141713-92-9 C₁₂H₁₁F₃O₃S 
• 1396980-07-6 C₁₄H₁₈F₃O₅P 
• 1210859-17-8 phenylamino-(4-trifluoromethyl-phenyl)-acetic acid methyl ester 
• 1210858-96-0 methyl 2-((2-fluorophenyl)amino)-2-(4-(trifluoromethyl)phenyl)acetate 
• 1332709-03-1 methyl 2-(1-methyl-1H-indol-3-yl)-2-(4-(trifluoromethyl)phenyl)acetate 
• 1210855-06-3 C₂₅H₂₁F₅N₂O 
• 1210855-09-6 C₂₅H₂₁F₅N₂O 
• 1210858-97-1 (2-Fluoro-phenylamino)-(4-trifluoromethyl-phenyl)-acetic acid 
• 1428670-06-7 C₁₅H₁₁F₄NO₂ 
• 1428670-07-8 C₁₅H₁₁F₄NO₂ 
• 906077-49-4 Phenylamino-(4-trifluoromethyl-phenyl)-acetic acid 
• 1210854-14-0 C₂₅H₂₂ClF₃N₂O 

Relevant academic research and scientific papers

PYRAZOLOTRIAZOLOPYRIMIDINE DERIVATIVES AS A2A RECEPTOR ANTAGONIST

Disclosed herein is a pyrazolotriazolopyrimidine derivative or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof useful as A2A receptor antagonist, and a pharmaceutical composition comprising the same. Also disclosed herein is a method of treating cancer using the pyrazolotriazolopyrimidine derivative or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof as A2A receptor antagonist.

NITROGENATED HETEROCYCLIC COMPOUND

The present invention provides a compound having a PDE2A selective inhibitory action, which is useful as an agent for the prophylaxis or treatment of schizophrenia, Alzheimer's disease and the like. The present invention is a compound represented by the formula (1): wherein each symbol is as described in the specification, or a salt thereof.

Synthesis of Quinolines by Visible-Light Induced Radical Reaction of Vinyl Azides and α-Carbonyl Benzyl Bromides

A visible-light induced radical reaction of vinyl azides and α-carbonyl benzyl bromides was developed, which provides an efficient route to polysubstituted quinolines via a C-C and C-N bond formation sequence.

MINERALOCORTICOID RECEPTOR ANTAGONISTS

The present invention is directed to compounds of the Formula I: as well as pharmaceutically acceptable salts thereof, that may be useful for treating aldosterone-mediated diseases. The invention furthermore relates to specific diastereomers and enantiome

Arylglycine derivatives as potent transient receptor potential melastatin 8 (TRPM8) antagonists

A series of arylglycine-based analogs was synthesized and tested for TRPM8 antagonism in a cell-based functional assay. Following structure-activity relationship studies in vitro, a number of compounds were identified as potent TRPM8 antagonists and were subsequently evaluated in an in vivo pharmacodynamic assay of icilin-induced 'wet-dog' shaking in which compound 12 was fully effective. TRPM8 antagonists of the type described here may be useful in treating pain conditions wherein cold hypersensitivity is a dominant feature.

Carbon-carbon bond-forming reactions of α-carbonyl carbocations: Exploration of a reversed-polarity equivalent of enolate chemistry

Carbon-carbon bond-forming reactions of putative α-carbonyl carbocation intermediates generated by Lewis acid- or silver-promoted ionizations of toluenesulfonate or halide leaving groups are described. This under-exploited mode of reactivity represents an 'umpolung' of conventional enolate chemistry, and enables C-C bond construction in both intra- and intermolecular contexts. Attempts to develop diastereoselective variants of this process using chiral ester and oxazolidinone-based auxiliaries are discussed.

PROCESS FOR PRODUCTION OF THIOPHENE COMPOUND AND INTERMEDIATE THEREOF

To provide a novel process for producing a 2-aryl-3-hydroxy-4-substituted carbonyl thiophene compound or an intermediate thereof useful as an intermediate for production of medicines and agricultural chemicals. A 2-aryl acetate compound represented by the formula (1): wherein R1 is an aryl group or the like, R4 is a C1-3 alkyl group or the like, and X is a leaving group, is reacted with a thioacetic acid compound to form a thioacetyl compound (3), the thioacetyl compound (3) is reacted with a vinyl ketone compound to form a γ-ketosulfide compound (5), which is cyclized under basic conditions to form a dihydrothiophene compound (6), and the dihydrothiophene compound (6) is oxidized by using an oxidizing agent to produce a 2-aryl-3-hydroxy-4-substituted carbonyl thiophene compound (7).

Cold Menthol Receptor Antagonists

Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein A, B, L, Q, R1, R2, and R3 /s

Photochemical synthesis of benz[h]isoquinolines

The synthesis of benz[h]isoquinolines has been achieved using a highly convergent photochemical method. The approach presented provides ready access to biologically active compounds and building blocks not readily available through other methods.

ALPHA-(TRIFLUOROMETHYL-SUBSTITUTED ARYLOXY, ARYLAMINO, ARYLTHIO OR ARYLMETHYL)-TRIFLUOROMETHYL-SUBSTITUTED PHENYLACETIC ACIDS AND DERIVATIVES AS ANTIDIABETIC AGENTS

Compounds having a formula (1) or a pharmaceutically acceptable salt or prodrug thereof, are provided, and are useful for the treatment of metabolic disorders.