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(1R,2S)-1-(4-Fluoro-phenyl)-cyclopropane-1,2-dicarboxylic acid is a chiral organic compound characterized by its unique molecular structure. It features a cyclopropane ring, which is a three-carbon ring, with two carboxylic acid groups attached to the first and second carbon atoms, respectively. The phenyl group is substituted at the 4-position with a fluorine atom, which imparts specific electronic and steric properties to the molecule. (1R,2S)-1-(4-Fluoro-phenyl)-cyclopropane-1,2-dicarboxylic acid is of interest in the field of organic chemistry, particularly in the synthesis of pharmaceuticals and other specialty chemicals, due to its potential to influence the reactivity and selectivity of chemical reactions. The chirality of the molecule, indicated by the (1R,2S) configuration, means that it has a non-superimposable mirror image, which is an important consideration in the development of enantiomerically pure drugs and other chiral molecules.

77053-79-3

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77053-79-3 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 77053-79-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,7,0,5 and 3 respectively; the second part has 2 digits, 7 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 77053-79:
(7*7)+(6*7)+(5*0)+(4*5)+(3*3)+(2*7)+(1*9)=143
143 % 10 = 3
So 77053-79-3 is a valid CAS Registry Number.

77053-79-3Relevant academic research and scientific papers

1-Aryl-3-azabicyclohexanes, a New Series of Nonnarcotic Analgesic Agents

Epstein, Joseph W.,Brabander, Herbert J.,Fanshawe, William J.,Hofmann, Corris M.,McKenzie, Thomas C.,et al.

, p. 481 - 490 (2007/10/02)

A series of 1-aryl-3-azabicyclohexanes was synthesized by hydride reduction of 1-arylcyclopropanedicarboximides.Hydroxyphenyl analogues 20, 22, and 24 were prepared by EtSNa-DMF ether cleavage of the corresponding methoxyphenyl analogues 2m, 2n, and 23, respectively, with the secondary amines 20 and 22 going through the N-formyl intermediates 19 and 21.The p-ethoxy analogue 26 was obtained by O-ethylation of 19, followed by base hydrolysis of the amide 25.The greatest analgesic potency in mouse writhing and rat paw-pain assays was observed for para-substituted compounds.Bicifadine, 1-(4-methylphenyl)-3-azabicyclohexane (2b), was the most potent member of the series and is presently undergoing clinical trials in man.Analgesic activity of 2b is limited to the (+) enantiomer 2v, which has the 1R,5S absolute configuration as determined by single-crystal X-ray analysis.The N-methyl analogue (27d) of 2b showed significant analgesic potency, whereas the N-allyl (27a), N-(cyclopropylmethyl) (27b), and N-(n-hexyl) (27c) analogues were inactive.Bicifadine (2b) showed a nonnarcotic profile different from analogous azabicycloalkane and 3-phenylpyrrolidine analgesics.

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