77064-57-4

Upstream product

• 67443-38-3 5-bromo-2-chloro-3-nitropyridine 
• 62-53-3 aniline 
• 15862-34-7 5-bromo-3-nitro-2-pyridone 

Downstream Products

• 221636-11-9 3-phenyl-6-(4-methoxylphenyl)imidazo[4, 5-b]pyridine 
• 221636-13-1 4-(3-phenyl-3H-imidazo[4,5-b]pyridin-6-yl)-phenol 
• 1404086-63-0 9-((6-amino-3-phenyl-3H-imidazo[4,5-b]pyridin-2-yl)methyl)-9H-purin-6-amine 
• 1404086-64-1 9-((6-methyl-3-phenyl-3H-imidazo[4,5-b]pyridin-2-yl)methyl)-9H-purin-6-amine 
• 1404085-40-0 6-bromo-2-(chloromethyl)-3-phenyl-3H-imidazo[4,5-b]pyridine 
• 1404085-42-2 9-((6-bromo-3-phenyl-3H-imidazo[4,5-b]pyridin-2-yl)methyl)-9H-purin-6-amine 

Relevant academic research and scientific papers

A Scaffold-Hopping Strategy toward the Identification of Inhibitors of Cyclin G Associated Kinase

We recently reported the discovery of isothiazolo[4,3-b]pyridine-based inhibitors of cyclin G associated kinase (GAK) displaying low nanomolar binding affinity for GAK and demonstrating broad-spectrum antiviral activity. To come up with novel core structures that act as GAK inhibitors, a scaffold-hopping approach was applied starting from two different isothiazolo[4,3-b]pyridines. In total, 13 novel 5,6- and 6,6-fused bicyclic heteroaromatic scaffolds were synthesized. Four of them displayed GAK affinity with Kd values in the low micromolar range that can serve as chemical starting points for the discovery of GAK inhibitors based on a different scaffold.

Imidazopyridine derivatives as PI3K inhibitors

New imidazopyridine derivatives having the chemical structure of formula (I) are disclosed; as well as process for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of Phosphoinositide 3-Kinases (PI3Ks)

IMIDAZOPYRIDINE DERIVATIVES AS PI3K INHIBITORS

New imidazopyridine derivatives having the chemical structure of formula (I) are disclosed; as well as process for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of Phosphoinositide 3-Kinases (PI3Ks).

Design and synthesis of 1,5-diarylbenzimidazoles as inhibitors of the VEGF-receptor KDR

1,5-Diarylbenzimidazoles have been identified as potent inhibitors of KDR kinase activity. The series was developed with a goal of finding compounds with optimal drug-like properties. This communication describes structural modifications in the series that enhance solubility, lower protein binding, and provide compounds with excellent potency and pharmacokinetic profiles.

REACTIVITIES OF HETEROCYCLIC COMPOUNDS IN NITRATION. 5. KINETICS OF NITRATION OF 5-SUBSTITUTED 2-PICRYLAMINOPYRIDINES

The kinetics of nitration of 5-bromo-, 5-chloro-, and 5-nitro-2-picrylaminopyridines in 80-96percent sulfuric acid were studied by a spectrophotometric method.The kinetic parameters of nitration were calculated.The UV spectra of the neutral and protonated forms in aqueous sulfuric acid solutions were identified.It was established that the indicated compounds are nitrated in the protonated form.The relative (as compared with benzene) rates of nitration were calculated.