7707-46-2Relevant academic research and scientific papers
1,2,4-Thiadiazolidin-3,5-diones as novel hydrogen sulfide donors
Severino, Beatrice,Corvino, Angela,Fiorino, Ferdinando,Luciano, Paolo,Frecentese, Francesco,Magli, Elisa,Saccone, Irene,Di Vaio, Paola,Citi, Valentina,Calderone, Vincenzo,Servillo, Luigi,Casale, Rosario,Cirino, Giuseppe,Vellecco, Valentina,Bucci, Mariarosaria,Perissutti, Elisa,Santagada, Vincenzo,Caliendo, Giuseppe
, p. 1677 - 1686 (2017/11/17)
Hydrogen sulfide (H2S) is an endogenous modulator that plays significant physio-pathological roles in several biological systems. In this research field there is a large interest in developing selective CBS and CSE inhibitors and H2S
Efficient Synthesis of 1,2,4-Dithiazolidine-3,5-diones (Dithiasuccinoyl-amines) and Observations on Formation of 1,2,4-Thiadiazolidine-3,5-diones by Related Chemistry
Slomczynska, Urszula,Barany, George
, p. 241 - 246 (2007/10/02)
An efficient synthesis of 1,2,4-dithiazolidine-3,5-diones (1) from chlorocarbonylsulfenyl chloride (3) plus O-dimethylaminoethyl-N-alkyl or aryl thiocarbamates (4) has been worked out.In this synthesis, 1,2,4-thiadiazolidine-3,5-diones (5) have been shown to arise as low-level-by-products, and experiments were conducted to elucidate the mechanism of the side reaction.N,N'-Dimethyl-1,2,4-thiadiazolidine-3,5-dione (5a) was prepared in one step from N,N'-dimethylurea plus 3, or from 4a plus one equivalent of sulfuryl chloride.A general route to 5 involved reaction ofequimolar amounts of isocyanates (6), isothiocyanates (7) and sulfuryl chloride followed by hydrolysis of intermediate 9.Heterocycles reported have been characterized by nmr, ir, uv, ms, and hplc.
