770738-36-8

Basic information

• Product Name: (R)-4-benzyl-3-{3-[(iodomethyl)dimethylsilyl]propanoyl}-1,3-oxazolidin-2-one
• Synonyms: (R)-4-benzyl-3-{3-[(iodomethyl)dimethylsilyl]propanoyl}-1,3-oxazolidin-2-one
• CAS NO: 770738-36-8
• Molecular Weight: 431.346
• Mol File: 770738-36-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (R)-4-benzyl-3-{3-[(iodomethyl)dimethylsilyl]propanoyl}-1,3-oxazolidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-4-benzyl-3-{3-[(iodomethyl)dimethylsilyl]propanoyl}-1,3-oxazolidin-2-one(770738-36-8)
• EPA Substance Registry System: (R)-4-benzyl-3-{3-[(iodomethyl)dimethylsilyl]propanoyl}-1,3-oxazolidin-2-one(770738-36-8)

Safety Data

• Hazardous Substances Data: 770738-36-8(Hazardous Substances Data)

Upstream product

• 770738-34-6 3-[(chloromethyl)(dimethyl)silyl]propanoic acid 
• 40217-17-2 (R)-4-(phenylmethyl)-2-oxazolidinone 
• 770738-35-7 (R)-4-benzyl-3-{3-[(chloromethyl)dimethylsilyl]propanoyl}-1,3-oxazolidin-2-one 

Downstream Products

• 770738-42-6 (4R)-3-{(2R)-2-azido-3-[(azidomethyl)dimethylsilyl]propanoyl}-4-benzyl-1,3-oxazolidin-2-one 
• 770738-52-8 (4R)-3-{(2S)-3-[(azidomethyl)dimethylsilyl]-2-bromopropanoyl}-4-benzyl-1,3-oxazolidin-2-one 
• 770738-48-2 (R)-2-amino-3-[hydroxydimethylsilyl]propanoic acid 
• 130835-27-7 (R)-4-benzyl-3-(prop-2-enoyl)-1,3-oxazolidin-2-one 
• 770738-38-0 (R)-3-{3-[(azidomethyl)dimethylsilyl]propanoyl}-4-benzyl-1,3-oxazolidin-2-one 
• 770738-39-1 2-[({3-[(4R)-4-benzyl-2-oxo-1,3-oxazolidin-3-yl]-3-oxopropyl}dimethylsilyl)methyl]-1H-isoindole-1,3(2H)-dione 

Relevant articles and documents

Towards functionalized silicon-containing α-amino acids: Asymmetric syntheses of sila analogs of homoserine and homomethionine

The homoserine and homomethionine sila analogs, (R)-HOSi(Me 2)CH2CH(NH2)CO2H ((R)-21) and (R)-MeSCH2Si(Me2)CH2CH(NH2)CO 2H ((R)-24), respectively, were each synthesized in nine steps and in 30 and 23% overall yield, respectively, from commercially available ClSiMe 2CH2Cl. The key step of both syntheses was the asymmetric α-bromination of an Evans amide to introduce the stereogenic center of the amino acids with defined absolute configuration. While the preparation of the homomethionine analog (R)-24 followed the expected pathway, the sila analog of homoserine, (R)-21, was unexpectedly formed during the catalytic hydrogenation of an N3CH2-substituted silane derivative.