770741-13-4

Upstream product

• 2577-90-4 methyl (2S)-2-amino-3-phenylpropanoate 
• 921204-91-3 (R)-2-(4-nitrobenzenesulfonyloxy)-3-phenylpropionic acid methyl ester 
• 676517-45-6 4-(3,4-dichloro-2-methylphenoxy)-1-(piperidin-4-ylmethyl)-piperidine 
• 27000-00-6 methyl 2-hydroxy-3-phenylpropionate 

Downstream Products

• 770741-51-0 (αS)-4-[[4-(3,4-dichloro-2-methylphenoxy)-1-piperidinyl]methyl]-α-(phenylmethyl)-1-piperidineacetic acid 

Relevant academic research and scientific papers

Scaffold-hopping with zwitterionic CCR3 antagonists: Identification and optimisation of a series with good potency and pharmacokinetics leading to the discovery of AZ12436092

The discovery and optimisation of a series of zwitterionic CCR3 antagonists is described. Optimisation of the structure led to AZ12436092, a compound with excellent selectivity over activity at hERG and outstanding pharmacokinetics in preclinical species.

NOVEL PIPERIDINE DERIVATIVES

The present invention provides a compound of a formula (I): wherein the variables are defined herein; to a process for preparing such a compound; and to the use of such a compound in the treatment of a chemokine (such as CCR3) mediated disease state.

CHEMICAL COMPOUNDS

The present invention provides a compound of a formula (I) wherein the variables are defined herein; to a process for preparing such a compound; and to the use of such a compound in the treatment of a chemokine (such as CCR3) or H1 mediated disease state.