77085-05-3Relevant academic research and scientific papers
Products from metallation and attempted metallation of 1-alkyl-4,6-diphenyl-2-pyridones and subsequent reaction with electrophiles
Katritzky, Alan Roy,Grzeskowiak, Nicholas E.,Salgado, Hector J.,bin Bahari, Zakaria
, p. 4451 - 4454 (1980)
The title pyridones form products in which either their own carbanion, or an alkylcarbanion, has added to the 3-position, followed by an electrophile to the 4-position.
Heterocycle Stabilized Carbanions. Two Series of Anomalous Products from 1-Alkyl-4,6-diphenyl-2-pyridones
Katritzky, Alan R.,Arrowsmith, John,Grzeskowiak, Nicholas E.,Salgado, Hector J.,Bahari, Zakaria bin
, p. 143 - 152 (2007/10/02)
1-Methyl-, 1-ethyl, and 1-n-butyl-4,6-diphenyl-2-pyridones with lithium di-isopropylamide yield normal products with ketone and aldehydes as electrophiles, but dimeric derivatives with acid chlorides, esters, and alkyl halides.The alkylpyridones react with ethyl- and n-butyl-lithium and an electrophile to give products resulting from alkylation at the 3- and reaction with electrophile at the 4-position.Structures are supported by spectra and reaction mechanisms discussed.
