77086-21-6Relevant articles and documents
Intermolecular Radical C(sp3)?H Amination under Iodine Catalysis
Bosnidou, Alexandra E.,Mu?iz, Kilian
, p. 7485 - 7489 (2019/04/30)
The direct amination of aliphatic C?H bonds has remained one of the most tantalizing transformations in organic chemistry. Herein, we report on a unique catalyst system, which enables the elusive intermolecular C(sp3)?H amination. This practical synthetic strategy provides access to aminated building blocks and fosters innovative multiple C?H amination within a new approach to aminated heterocycles. The synthetic utility is demonstrated by the synthesis of four relevant pharmaceuticals.
A BRIDGEHEAD α-AMINO CARBANION: FACILE PREPARATION OF C5(BRIDGEHEAD)-SUBSTITUTED ANALOGUES OF (+/-)-5H-DIBENZOCYCLOHEPTEN-5,10-IMINE INCLUDING A STABLE α-IODO SECONDARY AMINE
Monn, J. A.,Rice, K. C.
, p. 911 - 914 (2007/10/02)
The preparation of C5(bridgehead)-substituted analogues of (+/-)-5H-dibenzocyclohepten-5,10-imine via α-lithiation of a tert-butylformamidine precursor is presented.