77087-96-8Relevant academic research and scientific papers
Synthesis method of 2-chloro-4,6-dimethoxypyrimidine
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Paragraph 0011; 0020; 0023; 0024; 0028; 0031; 0032, (2018/03/23)
The invention provides a synthesis method of 2-chloro-4,6-dimethoxypyrimidine and belongs to the technical field of organic synthesis. A synthesis route that malononitrile, methanol, acetyl chloride,hydrogen cyanamide and alkali liquor are taken as raw materials is adopted, malononitrile is dropwise added into a system of malononitrile and methanol, 1,3-dimethamidine dihydrochloride is directly obtained, then reaction is carried out with sodium bicarbonate and hydrogen cyanamide to obtain 3-amino-3-methoxy-N-nitrile-2-propyl amidine, and further reaction is carried out with hydrogen chloride,so that 2-chloro-4,6-dimethoxypyrimidine is obtained. The synthesis method provided by the invention has the advantages that tedious synthesis process and equipment of 1,3-dimethamidine dihydrochloride are eliminated, acetyl chloride is added into the malononitrile and methanol, and 1,3-dimethamidine dihydrochloride is directly obtained by virtue of a one-step method. The synthesis route of 1,3-dimethamidine dihydrochloride has the advantages that moisture is controlled to be extremely low, product quality is stable and yield is high.
2-amino-4,6-dimethoxypyrimidine synthesis method
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Paragraph 0022; 0026; 0027; 0036, (2018/03/28)
The invention provides a 2-amino-4,6-dimethoxypyrimidine synthesis method, which belongs to the technical field of organic synthesis. The invention provides a synthetic route which takes malononitrile, methanol, acetyl chloride, hydrogen cyanamide and alkali liquor as raw materials; the method comprises the following steps of dropwise adding the acetyl chloride to a system of the malononitrile andthe methanol, directly obtaining 1,3-dimethylpropanediamidine dihydrochloride, then reacting with the alkali liquor and the hydrogen cyanamide to obtain 3-amino-3-methoxy-N-cyano-2-propylamidine andfurther performing closed-loop rearrangement to obtain 2-amino-4,6-dimethoxypyrimidine. The synthesis method provided by the invention saves the cumbersome synthesis technology and equipment of the 1,3-dimethylpropanediamidine dihydrochloride, and comprises the steps of adding the acetyl chloride into the malononitrile and the methanol to directly obtain the 1,3-dimethylpropanediamidine dihydrochloride. The synthetic route of the 1,3-dimethylpropanediamidine dihydrochloride in the invention has extremely low moisture control, stable product quality and high yield.
Integrated synthetic method of 2-amino-4,6-dimethoxypyrimidine
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Paragraph 0022; 0026; 0027; 0031; 0035; 0036, (2018/03/28)
The invention provides an integrated synthetic method of 2-amino-4,6-dimethoxypyrimidine, belongs to the technical field of organic synthesis, and provides a synthetic route using malononitrile, methanol, acetyl chloride, cyanamide and alkali liquid as raw materials. The integrated synthetic method comprises the following steps: dropwise adding acetyl chloride into a system of malononitrile and methanol to directly obtain 1,3-dimethyl propadiamidine dihydrochloride, and then performing reaction on 1,3-dimethyl propadiamidine dihydrochloride and the alkali liquid and cyanamide to obtain 3-amino-3-methoxyl-N-nitril-2-propa-amidine; directly heating, evaporating solvent and performing distillation to obtain 2-amino-4,6-dimethoxypyrimidine. According to the synthetic method disclosed by the invention, a synthetic process and equipment of 1,3-dimethyl propadiamidine dihydrochloride are simple, moisture control of the system is extremely low, the quality of the product is stable, and the yield is high. By adopting the integrated synthetic process, the synthetic process is reduced, distillation is carried out under reduced pressure so as to obtain 2-amino-4,6-dimethoxypyrimidine, and thepurity of the product is up to 99.99 percent.
Propenimidates
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, (2008/06/13)
Propenimidates are provided having the formula: STR1 wherein X and Y are independently O or S; and R1 and R2 are independently C1 -C4 alkyl, (CH2)n OR3 where R3 is C1 -C4 alkyl and n is 1 or 2, CH2 CH2 Cl, or CH2 CF3, provided that when R1 or R2 is CH2 CH2 Cl or CH2 CF3, then the respective X or Y is O. Preferred propenimidates have X and Y as O and R1 and R2 as methyl or ethyl. The propenimidates are made by preparing a monohydrohalide salt from a dihydrohalide salt of the formula: STR2 and then contacting the monohydrohalide salt with cyanamide. The propenimidates upon heating ring close to pyrimidines which are useful in preparing herbicidal compounds.
