77087-96-8

Basic information

• Product Name: methyl 3-amino-N-cyano-3-methoxyacrylimidate
• Synonyms: methyl 3-amino-N-cyano-3-methoxyacrylimidate;3-Amino-N-cyano-3-methoxy-2-propenimidic acid methyl ester
• CAS NO: 77087-96-8
• Molecular Formula: C6H9N3O2
• Molecular Weight: 155.15456
• EINECS: 278-615-0
• Mol File: 77087-96-8.mol
• Article Data: 4

Chemical Properties

• Melting Point: 116-121 °C
• Boiling Point: 210.473°C at 760 mmHg
• Flash Point: 81.091°C
• Appearance: /
• Density: 1.12g/cm³
• Vapor Pressure: 0.192mmHg at 25°C
• Refractive Index: 1.482
• PKA: 1.54±0.70(Predicted)
• CAS DataBase Reference: methyl 3-amino-N-cyano-3-methoxyacrylimidate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 3-amino-N-cyano-3-methoxyacrylimidate(77087-96-8)
• EPA Substance Registry System: methyl 3-amino-N-cyano-3-methoxyacrylimidate(77087-96-8)

Safety Data

• Hazardous Substances Data: 77087-96-8(Hazardous Substances Data)

Usage

InChI:InChI=1/C6H9N3O2/c1-10-5(8)3-6(11-2)9-4-7/h3H,8H2,1-2H3/b5-3+,9-6-

Upstream product

• 420-04-2 CYANAMID 
• 71160-05-9 dimethyl 1,3-propanediimidate dihydrochloride 

Relevant articles and documents

Synthesis method of 2-chloro-4,6-dimethoxypyrimidine

The invention provides a synthesis method of 2-chloro-4,6-dimethoxypyrimidine and belongs to the technical field of organic synthesis. A synthesis route that malononitrile, methanol, acetyl chloride,hydrogen cyanamide and alkali liquor are taken as raw materials is adopted, malononitrile is dropwise added into a system of malononitrile and methanol, 1,3-dimethamidine dihydrochloride is directly obtained, then reaction is carried out with sodium bicarbonate and hydrogen cyanamide to obtain 3-amino-3-methoxy-N-nitrile-2-propyl amidine, and further reaction is carried out with hydrogen chloride,so that 2-chloro-4,6-dimethoxypyrimidine is obtained. The synthesis method provided by the invention has the advantages that tedious synthesis process and equipment of 1,3-dimethamidine dihydrochloride are eliminated, acetyl chloride is added into the malononitrile and methanol, and 1,3-dimethamidine dihydrochloride is directly obtained by virtue of a one-step method. The synthesis route of 1,3-dimethamidine dihydrochloride has the advantages that moisture is controlled to be extremely low, product quality is stable and yield is high.

Integrated synthetic method of 2-amino-4,6-dimethoxypyrimidine

The invention provides an integrated synthetic method of 2-amino-4,6-dimethoxypyrimidine, belongs to the technical field of organic synthesis, and provides a synthetic route using malononitrile, methanol, acetyl chloride, cyanamide and alkali liquid as raw materials. The integrated synthetic method comprises the following steps: dropwise adding acetyl chloride into a system of malononitrile and methanol to directly obtain 1,3-dimethyl propadiamidine dihydrochloride, and then performing reaction on 1,3-dimethyl propadiamidine dihydrochloride and the alkali liquid and cyanamide to obtain 3-amino-3-methoxyl-N-nitril-2-propa-amidine; directly heating, evaporating solvent and performing distillation to obtain 2-amino-4,6-dimethoxypyrimidine. According to the synthetic method disclosed by the invention, a synthetic process and equipment of 1,3-dimethyl propadiamidine dihydrochloride are simple, moisture control of the system is extremely low, the quality of the product is stable, and the yield is high. By adopting the integrated synthetic process, the synthetic process is reduced, distillation is carried out under reduced pressure so as to obtain 2-amino-4,6-dimethoxypyrimidine, and thepurity of the product is up to 99.99 percent.