77093-89-1Relevant academic research and scientific papers
Highly Enantioselective Direct Synthesis of Endocyclic Vicinal Diamines through Chiral Ru(diamine)-Catalyzed Hydrogenation of 2,2′-Bisquinoline Derivatives
Ma, Wenpeng,Zhang, Jianwei,Xu, Cong,Chen, Fei,He, Yan-Mei,Fan, Qing-Hua
supporting information, p. 12891 - 12894 (2016/10/04)
An asymmetric hydrogenation of 2,2′-bisquinoline and bisquinoxaline derivatives, catalyzed by chiral cationic ruthenium diamine complexes, was developed. A broad range of chiral endocyclic vicinal diamines were obtained in high yields with excellent diastereo- and enantioselectivity (up to 93:7 dl/meso and >99 % ee). These chiral diamines could be easily transformed into a new class of chiral N-heterocyclic carbenes (NHCs), which are important but difficult to access.
Synthesis of Quinoxaline Derivatives through Condensation of 1,2-Diaminobenzenes with β-Keto Sulfoxides
Kano, Shinzo,Shibuya, Shiroshi,Yuasa, Yoko
, p. 1559 - 1561 (2007/10/02)
The reaction of o-phenylenediamine with α-methylsulfinylcyclohexanone and α-methylsulfinylcyclopentanone in the presence of acetic acid afforded 1,2,3,4-tetrahydrophenazine and 2,3-dihydro-1H-cyclopentaquinoxaline, respectively. 3,4-Diaminotoluene and 3,4-diaminochlorobenzene were reacted with α-methylsulfinylacetophenone to give a mixture of the corresponding 6- and 7-substituted 2-phenylquinoxaline.Condensation of 3,4-diaminomethoxybenzene with α-methylsulfinylacetophenone gave 7-methoxy-2-phenylacetophenone, whereas, the same reaction between 3,4-diaminonitrobenzene and α-methylsulfinylacetophenone yielded 6-nitro-2-phenylquinoxaline.
