77102-92-2

Usage

Uses

Used in Personal Care and Cosmetic Products:
3-chloro-2-methoxyphenol is used as a preservative and disinfectant for its antimicrobial properties, helping to inhibit the growth of bacteria and fungi in personal care and cosmetic products.
Used in Pharmaceutical Manufacturing:
3-chloro-2-methoxyphenol is utilized as an ingredient in the manufacturing of pharmaceuticals, contributing to the preservation and effectiveness of various medicinal products.
Used in Pesticide Production:
3-chloro-2-methoxyphenol is also used in the production of pesticides, where its antimicrobial properties help control the growth of harmful microorganisms in agricultural settings.
Used in Industrial Applications:
3-chloro-2-methoxyphenol finds use in other industrial applications due to its ability to act as a disinfectant and preservative, ensuring the longevity and safety of various products.
It is important to handle and use 3-chloro-2-methoxyphenol with caution, as it can be harmful if ingested, inhaled, or comes into contact with the skin. Proper safety measures should be taken to minimize any potential risks associated with this chemical compound.

InChI:InChI=1/C7H7ClO2/c1-10-7-5(8)3-2-4-6(7)9/h2-4,9H,1H3

Upstream product

• 4018-65-9 3-Chlorocatechol 
• 77-78-1 dimethyl sulfate 
• 223778-54-9 3-chloro-2-methoxybenzaldehyde 
• 1927-94-2 3-chlorosalicylaldehyde 

Downstream Products

• 602326-16-9 2,4-dibromo-5-chloro-6-methoxyphenol 
• 938-23-8 3,5,6-trichloroguaiacol 
• 1304581-59-6 C₂₇H₂₉Cl₂NO₆S 

Relevant academic research and scientific papers

α-Halogenation as a Strategy to Functionalize Cyclohexa-2,4-dienones

A facile pyridine-mediated α-halogenation approach to functionalize cyclohexa-2,4-dienones is developed. A range of reactions, including organometallic coupling protocols, have been applied on these newly obtained halogenated cyclohexa-2,4-dienones, and the results are presented herein.

A Mild meta-Selective C–H Alkylation of Catechol Mono-Ethers

Catechol mono-ethers are an important class of phenols. They are found in a number of pharmaceuticals, flavoring agents, perfumes, and are used for the preparation of numerous drugs. Herein, we report a mild meta-selective C–H alkylation of these phenols, which is enabled by a cascade of oxidative dearomatization – radical addition – rearomatization process. The method is compatible with reactive functional groups on the parent arenol, such as olefins and halides. Primary, secondary, and teriary alkyl groups can be used, the source of which is most commonly an alkylborane. This process is operationally simple, does not require heating and generally proceeds in good yields.

Novel compounds

The present invention provides compounds of Formula I wherein R1, R2, R3, and n have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment

Synthesis of hydroxylated and methoxylated polybrominated diphenyl ethers - Natural products and potential polybrominated diphenyl ether metabolites

Hydroxylated and methoxylated polybrominated diphenyl ethers (OH-PBDEs and MeO-PBDEs) may be natural products or they may be formed as metabolites of polybrominated diphenyl ethers (PBDEs), frequently used as flame retardants. The aim of this work was to synthesize authentic OH- and MeO-PBDE reference standards for analytical and toxicological studies. Brominated phenoxybenzaldehydes were prepared either by coupling of 2,4-dibromophenol with various fluorobenzaldehydes or by coupling of brominated hydroxybenzaldehydes with 2,2′,4,4′-tetrabromodiphenyliodonium chloride. OH-PBDEs were synthesized via the brominated phenoxybenzaldehydes by Baeyer-Villiger oxidation and acid-catalyzed hydrolysis. These OH-PBDEs were ortho- and para-brominated (relative to the hydroxy group) with benzyltrimethylammonium tribromide and/or orthobrominated with bromine/tert-butylamine, and were also brominated with bromine in one case. MeO-PBDEs were obtained by methylation of the prepared OH-PBDEs. MeO-PBDEs were also prepared through the coupling of brominated methoxyphenols with 2,2′,4,4′-tetrabromodiphenyliodonium salts, the corresponding OH-PBDEs being obtained after demethylation. A majority of the OH-/MeO-PBDEs prepared have the hydroxy/methoxy group in the ortho position relative to the diphenyl ether bond. All OH-/MeO-PBDEs prepared have 2,4-dibromo substitution patterns (relative to the diphenyl ether bond) in the non-hydroxy-/non-methoxy-containing ring. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003.

Limited Methylation of Chlorinated 1,2-Benzenediols to Chlorinated 2-Methoxyphenols

The reaction of chlorinated 1,2-benzenediols with dimethyl sulfate in NaOH solution has been investigated and found to result in chlorinated 2-methoxyphenols including three hitherto unknown compounds.Experimental and spectral data (mass, (1)H NMR, (13)C NMR) for all compounds are reported.