77103-49-2

Usage

Uses

Used in Fragrance Industry:
Benzenepropanoic acid, 3-hydroxy-β-oxo-, ethyl ester is used as a fragrance ingredient in perfumes for its sweet, floral scent.
Used in Flavor Industry:
Benzenepropanoic acid, 3-hydroxy-β-oxo-, ethyl ester is used as a flavoring agent in food products to impart a sweet, floral taste.
Used in Pharmaceutical Industry:
Benzenepropanoic acid, 3-hydroxy-β-oxo-, ethyl ester is utilized in the production of pharmaceuticals, contributing to the development of various medicinal compounds.
Used in Organic Synthesis:
Benzenepropanoic acid, 3-hydroxy-β-oxo-, ethyl ester serves as a reagent in organic synthesis processes, aiding in the creation of a range of chemical products.

Upstream product

• 121-71-1 3-Hydroxyacetophenone 
• 105-58-8 Diethyl carbonate 

Relevant academic research and scientific papers

Design, Synthesis, and Biochemical Characterization of Non-Native Antagonists of the Pseudomonas aeruginosa Quorum Sensing Receptor LasR with Nanomolar IC50 Values

Quorum sensing (QS), a bacterial cell-to-cell communication system mediated by small molecules and peptides, has received significant interest as a potential target to block infection. The common pathogen Pseudomonas aeruginosa uses QS to regulate many of its virulence phenotypes at high cell densities, and the LasR QS receptor plays a critical role in this process. Small molecule tools that inhibit LasR activity would serve to illuminate its role in P. aeruginosa virulence, but we currently lack highly potent and selective LasR antagonists, despite considerable research in this area. V-06-018, an abiotic small molecule discovered in a high-throughput screen, represents one of the most potent known LasR antagonists but has seen little study since its initial report. Herein, we report a systematic study of the structure-activity relationships (SARs) that govern LasR antagonism by V-06-018. We synthesized a focused library of V-06-018 derivatives and evaluated the library for bioactivity using a variety of cell-based LasR reporter systems. The SAR trends revealed by these experiments allowed us to design probes with 10-fold greater potency than that of V-06-018 and 100-fold greater potency than other commonly used N-acyl-l-homoserine lactone (AHL)-based LasR antagonists, along with high selectivities for LasR. Biochemical experiments to probe the mechanism of antagonism by V-06-018 and its analogues support these compounds interacting with the native ligand-binding site in LasR and, at least in part, stabilizing an inactive form of the protein. The compounds described herein are the most potent and efficacious antagonists of LasR known and represent robust probes both for characterizing the mechanisms of LuxR-type QS and for chemical biology research in general in the growing QS field.

METABOTROPIC GLUTAMATE RECEPTOR NEGATIVE ALLOSTERIC MODULATORS (NAMS) AND USES THEREOF

Provided herein are small molecule active metabotropic glutamate subtype-2 and -3 receptor negative allosteric modulators (NAMs), compositions comprising the compounds, and methods of using the compounds and compositions.

Flavonoids Syntheses. VI. Synthesis and Spectral Properties of 4-Arylcoumarins (Neoflavones)

Eight neoflavones were synthesized for examination of their spectral properties.In the mass spectra, 2'-oxygenated neoflavones showed characteristic fragments owing to dehydrxylation or demethoxylation.Other spectral data ultraviolet, proton and carbon-13 nuclear magnetic resonance, however, showed no specific features that could be used to characterize the structures.Keywords--neoflavone synthesis; 4-arylcoumarin; 2'-oxygenated neoflavone; mass spectrum