77119-86-9Relevant academic research and scientific papers
Design, synthesis and biological evaluation of hybrid of ubenimex-fluorouracil for hepatocellular carcinoma therapy
Hou, Xiaohan,Jia, Geng,Jiang, Yuqi,Li, Peixia,Li, Xiaoyang,Tan, Leqiao,Wang, Xuejian,Xu, Wenfang,Yue, Kairui,Zhang, Jian,Zhang, Liang,Zhang, Zhaolin
, (2021/09/22)
In our previous study, we discovered a ubenimex-fluorouracil (5FU) conjugates BC-02, which displays significant in vivo anti-tumor activity, however, the instability of BC-02 in plasma limits its further development as a drug candidate. Herein, we designe
Demonstration of direct binding of cIAP1 degradation-promoting bestatin analogs to BIR3 domain: Synthesis and application of fluorescent bestatin ester analogs
Sato, Shinichi,Aoyama, Hiroshi,Miyachi, Hiroyuki,Naito, Mikihiko,Hashimoto, Yuichi
scheme or table, p. 3354 - 3358 (2009/04/05)
Overexpression of cIAP1 correlates with resistance to radiotherapy and chemotherapy in various cancers. Recently, we reported that a class of bestatin ester analogs represented by MeBS (2) destabilized and promoted the degradation of cIAP1 through auto-ub
