77120-90-2

Upstream product

• 105-50-0 diethyl 1,3-acetonedicarboxylate 
• 100-46-9 benzylamine 

Downstream Products

• 77120-93-5 (2R,3R,4S)-4-Benzylamino-2-methyl-6-oxo-tetrahydro-pyran-3-carboxylic acid; hydrochloride 
• 77120-92-4 (2R,3S)-3-Benzylamino-2-((R)-1-hydroxy-ethyl)-pentanedioic acid diethyl ester 
• 77120-91-3 (E)-2-Acetyl-3-benzylamino-pent-2-enedioic acid diethyl ester 

Relevant academic research and scientific papers

A PRACTICAL SYNTHESIS OF (+/-)-THIENAMYCIN

An efficient and operationally simply synthesis of (+/-)-thienamycin is described.

Process for preparation of substituted pyridines

Disclosed herein is a novel process for the preparation of 4-amino-3,5-pyridinedicarboxylate derivatives by (a) reaction of an acetonediester with a primary amine to form an enamine, (b) reaction with a carboxylic acid anhydride or halide to form a 2-alky

Herbicidal (2 or 6)-fluoroalkyl-4-amino pyridine derivatives

Disclosed herein are 3,5-pyridinedicarboxylic acid derivatives having heteroatom substitution at the 4 position which are useful as herbicides and herbicide precursors.

Intermediate for synthesis of thienamycin via (3SR, 4RS)-3-[1 (SR)-hydroxyethyl]-2-oxo-4-azetidineacetic acid

Disclosed is a process for the stereocontrolled total synthesis of thienamycin via intermediates II and IIa: STR1 wherein R is a readily removable carboxyl protecting group.

Intermediate for the preparation of thienamycin

Disclosed is a process for the stereocontrolled total synthesis of thienamycin from acetone dicarboxylate via intermediate II: STR1 wherein R is a readily removable carboxyl protecting group.

Synthesis of thienamycin via esters of (3SR, 4RS)-3-[(SR)-1-hydroxyethyl]-β,2-dioxo-4-azetidinebutanoic acid

Disclosed is a process for the stereocontrolled total synthesis of thienamycin, which synthesis proceeds via intermediate II: STR1 wherein R3 is a readily removable carboxyl protecting group.

Synthesis of thienamycin via (3SR, 4RS)-3-((RS)-1-acyloxyethyl)-2-oxo-4-azetidineacetate

Disclosed is a process for the stereocontrolled total synthesis of thienamycin, which synthesis proceeds via intermediate II: STR1 wherein R is a readily removable carboxyl protecting group; and STR2 is a readily removable acyl group.