77130-12-2

Upstream product

• 22980-09-2 indolyl-3-glyoxylyl chloride 
• 60900-14-3 1-benzyl-3-ethyl-1,2,5,6-tetrahydropyridine 
• 98-59-9 p-toluenesulfonyl chloride 
• 77612-53-4 indol-3-ylglyox(1,2,5,6-tetrahydro-3-ethylpyridine)amide 
• 88839-88-7 1-tosylindol-3-ylglyox(1,2,5,6-tetrahydro-3-ethylpyridine)amide 
• 10250-48-3 methyl 3,3-dimethylbutyrate 
• 88839-89-8 1-tosylindol-3-ylglycol(1,2,5,6-tetrahydro-3-ethylpyridine)amide 
• 87167-73-5 1-benzyl-3-ethyl-pyridinium chloride 
• 77612-52-3 3-ethyl-1-methoxycarbonyl-1,2,5,6-tetrahydropyridine 
• 536-78-7 3-ethylpyridine 

Downstream Products

• 77139-03-8 2-[3-[2-(5-Ethyl-3,6-dihydro-2H-pyridin-1-yl)-ethyl]-1-(toluene-4-sulfonyl)-1H-indol-2-yl]-acrylic acid methyl ester 
• 88839-92-3 2-[3-[2-(11-Ethyl-3,5-dioxo-4-phenyl-2,4,6,8-tetraaza-tricyclo[5.2.2.0^2,6]undec-10-en-8-yl)-2-oxo-ethyl]-1-(toluene-4-sulfonyl)-1H-indol-2-yl]-acrylic acid methyl ester 
• 88839-91-2 5-oxo-N_a-14,21-dehydrosecodine 
• 88839-87-6 2-oxo-3-methyl-3-carbomethoxy-4-tosyl-cyclopentindole 
• 88839-90-1 methyl α-<1-tosylindol-3-acetic(trans-3,4-dibromo-3-ethylpiperidine)amide-2-yl>acrylate 
• 77130-14-4 2-[3-[2-(5-Ethyl-3,6-dihydro-2H-pyridin-1-yl)-2-thioxo-ethyl]-1-(toluene-4-sulfonyl)-1H-indol-2-yl]-acrylic acid methyl ester 

Relevant academic research and scientific papers

INTRAMOLECULAR HYDRIDE TRANSFER AND CYCLIZATION OF 5-OXO-Na-TOSYL-14,21-DEHYDROSECODINE

5-Oxo-Na-tosyl-14,21-dehydrosecodine (8) was prepared by bromination of 6 followed by double dehydrobromination with ethyl aluminum dichloride in HMPA.When a dilute solution of 8 was heated, 10 was formed via intramolecular hydride transfer and cyclization.