77134-02-2

Usage

Chemical class

Pyridines and derivatives

Structure

Ester derivative of 1,2-Diazabicyclo[5.2.0]nona-3,5-diene-2-carboxylic acid

Functionality

Used as a catalyst in various chemical reactions

Form

Ethyl ester

Application

Organic synthesis as a base or a ligand in catalytic reactions

Industries

Pharmaceutical and agrochemical

Usage

Synthesis of pharmaceutical drugs and crop protection agents

Mechanism

Facilitates reactions by acting as a base and aiding in the formation of new bonds between different molecules

Upstream product

• 6004-44-0 prop-1-en-1-one 
• 22928-91-2 ethyl 5-methyl-1H-1,2-diazepine-1-carboxylate 

Relevant academic research and scientific papers

Methylketene: Synthesis by Pyrolysis of Butanone and Reaction with Imines Yielding Methylated Azetidinones

During the pyrolysis of acetone with a ketene lamp trace amounts of butanone and methylketene are produced.These compounds result from break-off reactions of radical reaction chains of acetone.Pyrolysis of butanone leads to a mixture of ketene (70percent) and methylketene (30percent).The latter reacts with imines to give methylated β-lactams.The rate of these cycloaddition reactions is several powers of ten greater than the one observed with ketene.The 8-methyl-5-azanonamdienes 7, 10, 26, and 31 are obtained in good yields when the corresponding diazepines are reacted with the pyrolysis gas of butanone.Similar experimental conditions lead to the methylated azetidinones 13, 15, 16, and 18 in moderate yields whereas the known thiazolines 19, 20, and 21 do not react at all.The action of 26 and 30 against several pathogenic bacterial strains was tested; however, no antibacterial properties could be detected.