77140-72-8

Upstream product

• 1885-14-9 phenyl chloroformate 
• 2357-47-3 4-Fluoro-3-trifluoromethylaniline 

Downstream Products

• 70842-08-9 5-Imino-4,4-dimethyl-1-(α,α,α,4-tetrafluor-m-tolyl)-2-imidazolidinon 
• 70842-04-5 5,5-dimethyl-3-(α,α,α,4-tetrafluoro-m-tolyl)hydantoin 
• 92668-58-1 5,5-Dimethyl-2,4-dioxo-3-(α,α,α,4-tetrafluor-m-tolyl)-1-imidazolidincarbonsaeureethylester 
• 92668-59-2 5,5-Dimethyl-1-nitro-3-(α,α,α,4-tetrafluor-m-tolyl)hydantoin 
• 92668-63-8 N-<5,5-Dimethyl-2-oxo-3-(α,α,α,4-tetrafluor-m-tolyl)-4-imidazolidinyliden>acetamid 
• 92668-62-7 4,4-Dimethyl-5-(ethylimino)-1-(α,α,α,4-tetrafluor-m-tolyl)-2-imidazolidinon 

Relevant academic research and scientific papers

Synthesis of 4-oxotetrahydropyrimidine-1(2H)-carboxamides derivatives as capsid assembly modulators of hepatitis B virus

We report herein the synthesis and evaluation of phenyl ureas derived from 4-oxotetrahydropyrimidine as novel capsid assembly modulators of hepatitis B virus (HBV). Among the derivatives, compound 27 (58031) and several analogs showed an activity of submi

6,7-DIHYDRO-4H-PYRAZOLO[1,5-A]PYRAZINE AND 6,7-DIHYDRO-4H-TRIAZOLO[1,5-A]PYRAZINE COMPOUNDS FOR THE TREATMENT OF INFECTIOUS DISEASES

The present invention relates to compounds of the formula (I), or pharmaceutically acceptable salts, enantiomer or diastereomer thereof, wherein R1 to R4 and Q are as described above. The compounds may be useful for the treatment or prophylaxis of hepatitis B virus infection.

CYCLOPROPANECARBOXAMIDO-SUBSTITUTE AROMATIC COMPOUNDS AS ANTI-TUMOR AGENTS

Provided are cyclopropanecarboxamido-substituted aromatic compounds that inhibit protein kinases and their use in anti-tumor area. In particular, tyrosine-kinase inhibitors and Raf-kinase inhibitors as anti-tumor agents, their preparation, pharmaceutical composition, and their use in the treatment of cancer are also provided.

SPIROCYCLIC PIPERIDINE DERIVATIVES AS TRPM 8 MODULATORS

The present invention provides Transient Receptor Potential subfamily M, member 8 (TRPM8) modulators of formula (I). In particular, compounds described herein are useful for treating or preventing diseases, conditions and/or disorders modulated by TRPM8.

3-Arylhydantoine, a class of schistosomicidal compounds

A series of derivatives of 3-arylhydantoin was synthesized and submitted to a broad pharmacological screening. Unexpectedly, some of the tested compounds showed interesting activity against infection with Schistosoma mansoni. From a study on structure-act