77143-70-5 Usage
Type of compound
Potent and selective inhibitor of cyclooxygenase-2 (COX-2)
Classification
Nonsteroidal anti-inflammatory drug (NSAID)
Mechanism of action
Blocks the production of prostaglandins, which cause pain and inflammation in the body
Potential uses
Treatment of various inflammatory conditions, including arthritis, cancer, and neurodegenerative diseases
Research applications
Studying the role of COX-2 in different physiological and pathological processes
Preclinical results
Shown promise in preclinical studies
Safety and efficacy
Further research needed to fully understand its therapeutic potential and safety profile.
Check Digit Verification of cas no
The CAS Registry Mumber 77143-70-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,7,1,4 and 3 respectively; the second part has 2 digits, 7 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 77143-70:
(7*7)+(6*7)+(5*1)+(4*4)+(3*3)+(2*7)+(1*0)=135
135 % 10 = 5
So 77143-70-5 is a valid CAS Registry Number.
InChI:InChI=1/C17H14O4/c1-10(16(18)19)12-7-8-14-13(9-12)15(17(20)21-14)11-5-3-2-4-6-11/h2-10,15H,1H3,(H,18,19)
77143-70-5Relevant academic research and scientific papers
Benzofuran Derivatives: Part III - Rearrangement During Cyclization of Ethyl &α-(4-Methoxycarbonylalkylphenoxy)arylacetates and Formation of 3-Aryl-2(3H)-benzofuranone-5-alkanoic Acid Esters
Shridhar, D. R.,Sastry, C. V. Reddy,Mehrotra, A. K.,Bansal, O. P.
, p. 891 - 893 (2007/10/02)
Treatment of ethyl α-(4-methoxycarbonylalkylphenoxy)arylacetates (III) with conc.H2SO4 or PPA leads to 3-aryl-2(3H)-benzofuranone-5-alkanoic acid esters (V), via rearrangement and cyclization.Acid hydrolysis of V furnishes 3-aryl-2(3H)-benzofuranone-5-alkanoic acids (VI).These compounds show a moderate antiinflammatory activity.
