77152-97-7

Usage

Uses

Used in Organic Synthesis:
TERT-BUTYL N-(3-AMINO-3-THIOXOPROPYL)CARBAMATE is used as a reagent in organic synthesis for its ability to form various chemical compounds and contribute to the development of new molecules with potential applications.
Used in Pharmaceutical Research:
In the pharmaceutical industry, TERT-BUTYL N-(3-AMINO-3-THIOXOPROPYL)CARBAMATE is utilized as a research compound to explore its potential therapeutic properties. Its interaction with biological targets makes it a promising candidate for the development of new drugs and treatments.
Used in Drug Development:
TERT-BUTYL N-(3-AMINO-3-THIOXOPROPYL)CARBAMATE is employed in drug development as a starting material or intermediate in the synthesis of pharmaceutical compounds. Its unique structure and functional group provide opportunities for the creation of novel therapeutic agents.

InChI:InChI=1/C8H16N2O2S/c1-8(2,3)12-7(11)10-5-4-6(9)13/h4-5H2,1-3H3,(H2,9,13)(H,10,11)

Upstream product

• 53588-95-7 3-<(tert-butoxycarbonyl)amino>propionitrile 
• 3303-84-2 3-(tert-butyloxycarbonylamino)propionic acid 
• 24424-99-5 di-tert-butyl dicarbonate 
• 65983-35-9 (2-carbamoyl-ethyl)-carbamic acid tert-butyl ester 

Downstream Products

• 141424-43-3 {2-[5,6-Bis-(4-methoxy-phenyl)-[1,2,4]triazin-3-yl]-ethyl}-carbamic acid tert-butyl ester 
• 1171113-93-1 tert-butyl {2-[4-(5-phenyloxazol-2-yl)thiazol-2-yl]ethyl}carbamate 
• 1171113-94-2 2-[2-(2-aminoethyl)thiazol-4-yl]-5-phenyloxazole 
• 77153-02-7 N-benzoyl-3-<(tert-butoxycarbonyl)amino>propionamidine 
• 77172-36-2 3-<(tert-butoxycarbonyl)amino>propionamidine 

Relevant academic research and scientific papers

Synthesis of novel amide and urea derivatives of thiazol-2-ethylamines and their activity against Trypanosoma brucei rhodesiense

2-(2-Benzamido)ethyl-4-phenylthiazole (1) was one of 1035 molecules (grouped into 115 distinct scaffolds) found to be inhibitory to Trypanosoma brucei, the pathogen causing human African trypanosomiasis, at concentrations below 3.6 μM and non-toxic to mammalian (Huh7) cells in a phenotypic high-throughput screen of a 700,000 compound library performed by the Genomics Institute of the Novartis Research Foundation (GNF). Compound 1 and 72 analogues were synthesized in this lab by one of two general pathways. These plus 10 commercially available analogues were tested against T. brucei rhodesiense STIB900 and L6 rat myoblast cells (for cytotoxicity) in vitro. Forty-four derivatives were more potent than 1, including eight with IC50 values below 100 nM. The most potent and most selective for the parasite was the urea analogue 2-(2-piperidin-1-ylamido)ethyl-4-(3-fluorophenyl)thiazole (70, IC50 = 9 nM, SI > 18,000). None of 33 compounds tested were able to cure mice infected with the parasite; however, seven compounds caused temporary reductions of parasitemia (≥97%) but with subsequent relapses. The lack of in vivo efficacy was at least partially due to their poor metabolic stability, as demonstrated by the short half-lives of 15 analogues against mouse and human liver microsomes.

A convenient synthesis of ethyl 3-aminopropanedithioate (β-alanine ethyl dithioester)

A five-step sequence allowing the preparation of ethyl 3- aminopropanedithioate from N-(Boc)-β-alanine via the key intermediate N- (Boc)-β-alaninethioacyl-N-phthalimide is described.

Dithio and thiono esters, LVII: Synthesis of dithio and thiono esters of N-protected β- and γ-amino acids

The N-protected β-aminonitriles 1 were transformed into the imidoester or thiolimidoester hydrochlorides 2 or 3 according to Pinner and sulfhydrolyzed with H2S to give the N-protected β-amino thiono esters 4 or dithio esters 5. Alkylation of th

Acylation of Dibasic Compounds Containing Amino Amidine and Aminoguanidine Functions

The site of acylation in difunctional compounds containing an amine and either an amidine or guanidine can be determined from the ultraviolet absorption spectrum of the acylated product.If the amidine or guanidine has been acylated, the product possesses a chromophore that is pH dependent, whereas if an amide was formed, the chromophore is independent of pH.