77153-45-8

Upstream product

• 1122-91-4 4-bromo-benzaldehyde 
• 1073-67-2 4-vinylbenzyl chloride 
• 6332-22-5 1-(4-bromophenyl)-3-(4-chlorophenyl)prop-2-en-1-one 
• 122652-39-5 3-(4-Bromo-phenyl)-5-(4-chloro-phenyl)-4,5-dihydro-1H-pyrazole 

Downstream Products

• 77153-55-0 (cis)-1-(p-Chlorophenyl)-2-(p-cyanophenyl)cyclopropane 
• 77153-40-3 (cis)-1-p-biphenylyl-2-(p-methoxyphenyl)cyclopropane 
• 77153-56-1 (trans)-1-(p-Chlorophenyl)-2-(p-cyanophenyl)cyclopropane 

Relevant academic research and scientific papers

FUSED HETEROCYCLIC COMPOUNDS AS S1P MODULATORS

The invention relates to heterocyclic compounds as S1P modulators, pharmaceutical compositions comprising such compounds, and uses thereof in the treatment, alleviation or prevention of diseases or disorders mediated by an S1P receptor.

Kinetic Study of the Homolytic Brominolysis of 1,2-Diarylcyclopropanes

The rate constants for the photolytic brominolysis of 22 trans-1,2-diarylcyclopropanes in carbon disulfide relative to an internal standard, p-chlorotoluene, have been determined.The products of the brominolysis are 1,3-dibromo-1,3-diarylpropanes.The rate constants range over 5 orders of magnitude, being enhanced by electrondonating substituents on one or both benzene rings.The quantitative size of the substituent effect (ρ) at either involved carbon center is a function of the substituent at the other center.This fact suggests a continuum of transition-state structures with varying degrees of bond breaking and charge separation.