771553-62-9Relevant academic research and scientific papers
Discovery of a new class of glucosylceramide synthase inhibitors
Koltun, Elena,Richards, Steven,Chan, Vicky,Nachtigall, Jason,Du, Hongwang,Noson, Kevin,Galan, Adam,Aay, Naing,Hanel, Art,Harrison, Amanda,Zhang, Jeff,Won, Kwang-Ai,Tam, Danny,Qian, Fawn,Wang, Tao,Finn, Patricia,Ogilvie, Kathleen,Rosen, Jon,Mohan, Raju,Larson, Christopher,Lamb, Peter,Nuss, John,Kearney, Patrick
scheme or table, p. 6773 - 6777 (2011/12/05)
A novel series of potent inhibitors of glucosylceramide synthase are described. The optimization of biochemical and cellular potency as well as ADME properties led to compound 23c. Broad tissue distribution was obtained following oral administration to mice. Thus 23c could be another useful tool compound for studying the effects of GCS inhibition in vitro and in vivo.
PDE4 INHIBITORS SELECTIVE FOR THE LONG FORM OF PDE4 FOR TREATING INFLAMMATION AND AVOIDING SIDE EFFECTS
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Page/Page column 121-122, (2010/07/10)
The present invention relates to compounds which are inhibitors of phosphodiesterase-4 (PDE4) useful for the treatment and prevention of stroke, myocardial infarct, cardiovascular inflammatory diseases and disorders and central nervous system disorders, t
A new chemical tool for exploring the role of the PDE4D isozyme in leukocyte function
Chambers, Robert J.,Abrams, Kristin,Castleberry, Tessa A.,Cheng, John B.,Fisher, Douglas A.,Kamath, Ajith V.,Marfat, Anthony,Nettleton, David O.,Pillar, Joann D.,Salter, Eben D.,Sheils, Alissa L.,Shirley, John T.,Turner, Claudia R.,Umland, John P.,Lam, Kelvin T.
, p. 718 - 721 (2007/10/03)
Nicotinamide (2) is a potent and selective inhibitor of the PDE4D isozyme and as a chemical tool selectively blocks eosinophil mediator release and chemotaxis thus linking the role of PDE4D to eosinophil function.
