771583-12-1

Basic information

• Product Name: 2-(AMINOMETHYL)-4-BROMOANILINE
• Synonyms: RARECHEM AL BW 1235;2-(AMINOMETHYL)-4-BROMOANILINE;2-(Aminomethyl)-4-boroaniline;2-AMinoMethyl-4-broMophenylaMine;Benzenemethanamine,2-amino-5-bromo-
• CAS NO: 771583-12-1
• Molecular Formula: C₇H₉BrN₂
• Molecular Weight: 201.06
• Mol File: 771583-12-1.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 308.5±27.0 °C(Predicted)
• Appearance: /
• Density: 1.572±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 9.30±0.10(Predicted)
• CAS DataBase Reference: 2-(AMINOMETHYL)-4-BROMOANILINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(AMINOMETHYL)-4-BROMOANILINE(771583-12-1)
• EPA Substance Registry System: 2-(AMINOMETHYL)-4-BROMOANILINE(771583-12-1)

Safety Data

• Hazardous Substances Data: 771583-12-1(Hazardous Substances Data)

Usage

General Description

2-(aminomethyl)-4-bromoaniline is a chemical compound with the molecular formula C7H8BrN2. It is a derivative of aniline, containing a bromine atom and an amino group attached to a methyl group. 2-(AMINOMETHYL)-4-BROMOANILINE is commonly used in organic synthesis and pharmaceutical research. It has potential applications in the manufacturing of dyes, pigments, and pharmaceuticals. The presence of both an amine and bromine functional groups makes it a versatile building block for the synthesis of various organic compounds. However, due to its potential reactivity and toxicity, proper handling and safety precautions are necessary when working with this chemical.

Upstream product

• 39263-32-6 2-amino-5-bromobenzonitrile 
• 1004997-73-2 2-(aminomethyl)-4-bromoaniline dihydrochloride 

Downstream Products

• 1004997-73-2 2-(aminomethyl)-4-bromoaniline dihydrochloride 
• 1246765-38-7 6-bromo-3,4-dihydroquinazolin-2(1H)-one 
• 1201902-00-2 [6-(2-methyl-1H-imidazol-1-yl)-2-phenyl]quinazoline 
• 1004997-71-0 [2-phenyl-6-(1H-imidazol-1-yl)]quinazoline 
• 1201902-24-0 6-bromo-2-phenyl-3,4-dihydroquinazoline 
• 1428149-59-0 2-bromo-8-((4-methoxybenzyl)oxy)-6,7,8,9,10,12-hexahydroazepino[2,1-b]quinazoline 
• 1428149-50-1 6'-bromo-4-((4-methoxybenzyl)oxy)-3',4'-dihydro-1'H-spiro[cyclohexane-1,2'-quinazoline] 
• 1228552-83-7 [(S)-1-((S)-2-{5-[4-(6-{2-[(S)-1-((S)-2-methoxycarbonylamino-3-methylbutyryl)-pyrrolidin-2-yl]-3H-imidazol-4-yl}-quinazolin-2-yl)-phenyl]-1H-imidazol-2-yl}-pyrrolidine-1-carbonyl)-2-methyl-propyl]carbamic acid methyl ester 
• 1261071-79-7 tert-butyl (2S)-2-(5-{2-[4-(2-[(2S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl]-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-5-yl)phenyl]quinazolin-6-yl}-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl)pyrrolidine-1-carboxylate 
• 1228552-80-4 (S)-2-[5-(4-{6-[2-((S)-1-carboxylic acid tert-butyl ester-pyrrolidin-2-yl)-3H-imidazol-4-yl]quinazolin-2-yl}phenyl)-1H-imidazol-2-yl]pyrrolidine-1-carboxylic acid tert-butyl ester 
• 1261071-78-6 (S)-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-[2-(4-{6-[2-((S)-1-carboxylic acid tert-butyl-ester-pyrrolidine-2-carbonyloxy)acetyl]quinazolin-2-yl}phenyl)-2-oxoethyl] ester 
• 1261071-77-5 2-bromo-1-{2-[4-(2-bromoacetyl)phenyl]quinazolin-6-yl}ethanone 
• 1261071-76-4 2,2-dibromo-1-{2-[4-(2,2-dibromoacetyl)phenyl]quinazolin-6-yl}ethanone 
• 1261071-75-3 6-(1-ethoxyethenyl)-2-[4-(1-ethoxyethenyl)phenyl]quinazoline 

Relevant articles and documents

Base-Promoted Synthesis of 2-Aryl Quinazolines from 2-Aminobenzylamines in Water

A transition-metal-free procedure for the synthesis of a highly valuable class of heteroaromatics, quinazolines, was developed by using easily available 2-aminobenzylamines and α,α,α-trihalotoluenes. The transformation proceeded smoothly in the presence of only sodium hydroxide and molecular oxygen in water at 100 °C, furnishing a variety of 2-aryl quinazolines. The crystallization process of the crude reaction mixture for the purification of the solid products circumvents huge solvent-consuming workup and column chromatographic techniques, which make the overall process more sustainable and economical.

Derisking the Cu-Mediated 18F-Fluorination of Heterocyclic Positron Emission Tomography Radioligands

Molecules labeled with fluorine-18 (18F) are used in positron emission tomography to visualize, characterize and measure biological processes in the body. Despite recent advances in the incorporation of 18F onto arenes, the development of general and efficient approaches to label radioligands necessary for drug discovery programs remains a significant task. This full account describes a derisking approach toward the radiosynthesis of heterocyclic positron emission tomography (PET) radioligands using the copper-mediated 18F-fluorination of aryl boron reagents with 18F-fluoride as a model reaction. This approach is based on a study examining how the presence of heterocycles commonly used in drug development affects the efficiency of 18F-fluorination for a representative aryl boron reagent, and on the labeling of more than 50 (hetero)aryl boronic esters. This set of data allows for the application of this derisking strategy to the successful radiosynthesis of seven structurally complex pharmaceutically relevant heterocycle-containing molecules.

Ynthesis of 6-piperazinyl-3,4-dihydroquinazolin-2(1H)-ones

A series of new 6-piperazinyl-3,4-dihydroquinazolin-2(1H)-ones have been synthesized. The described compounds are structurally related to adoprazine, a potential atypical antipsychotics bearing potent D2 receptor antagonist and 5-HT1A receptor agonist pro