77161-36-5Relevant academic research and scientific papers
SINTESI DI p-AMMINOBENZENSOLFONILDIAZINE
Desideri, N.,Manna, F.,Stein, M. L.,Arena, F.,Luraschi, E.,Cifra, E.
, p. 902 - 912 (2007/10/02)
New sulfones were synthesized; these are analogues of bis-(4-aminophenyl)sulfone (DDS) but contain, instead of one benzene nucleus, a heterocycle that is a pyrimidine, pyrazine or pyridazine nucleus.This was substituted with amine, methoxy, methyl groups or halogens in order to obtain long-acting drugs, similarly to those obtained in the field of sulfonamides.The synthesis was accomplished by reaction of sodium p-amino- or p-acetamidobenzenesulfinate with the corresponding halodiazine; only the p-aminophenyl 3-aminopyridazin-6-yl sulfone was obtained by acid hydrolysis.The compounds showed good antitubercular activity in vitro.
