77165-77-6 Usage
Chemical compound
1,11a-didehydroanhydroanthramycin is a chemical compound that belongs to the anthramycin family of antibiotics.
Unique structure
It is characterized by its unique structure, which includes an anthraquinone core that is essential for its biological activity.
Medicinal chemistry potential
1,11a-didehydroanhydroanthramycin has shown promising potential in the field of medicinal chemistry, particularly in the treatment of cancer.
DNA targeting
Its ability to target specific DNA sequences and inhibit the growth of cancer cells makes it a valuable candidate for the development of novel anticancer drugs.
Antibacterial activity
1,11a-didehydroanhydroanthramycin has demonstrated potent antibacterial activity, making it a versatile compound with potential applications in both cancer therapy and infectious disease treatment.
Ongoing research and development
Its complex structure and multifaceted biological properties make it a subject of ongoing research and development in the pharmaceutical industry.
Anticancer drug development
Due to its DNA targeting and cancer cell growth inhibition properties, 1,11a-didehydroanhydroanthramycin is a promising candidate for the development of new anticancer drugs.
Versatility
The compound's potent antibacterial activity, in addition to its anticancer properties, makes it a versatile compound with potential applications in various areas of medicine.
Pharmaceutical industry interest
The unique structure and multifaceted biological properties of 1,11a-didehydroanhydroanthramycin have attracted the attention of the pharmaceutical industry, leading to ongoing research and development efforts.
Check Digit Verification of cas no
The CAS Registry Mumber 77165-77-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,7,1,6 and 5 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 77165-77:
(7*7)+(6*7)+(5*1)+(4*6)+(3*5)+(2*7)+(1*7)=156
156 % 10 = 6
So 77165-77-6 is a valid CAS Registry Number.
InChI:InChI=1/C16H13N3O3/c1-9-2-4-12-14(15(9)21)18-7-11-6-10(3-5-13(17)20)8-19(11)16(12)22/h2-8,21H,1H3,(H2,17,20)/b5-3+
77165-77-6Relevant academic research and scientific papers
Rahman, Khondaker M.,James, Colin H.,Thurston, David E.
, p. 1632 - 1641 (2011)
Pyrrolobenzodiazepines (PBDs) are sequence-selective DNA minor-groove binding agents that covalently bond to guanine with a reported preference for Pu-G-Pu sequences (Pu = Purine). Using HPLC/MS and Circular Dichroism (CD) methodologies, we have established for the first time that the aminal bond formed between PBD molecules and DNA is reversible. Furthermore, we have shown that while the rate of aminal bond cleavage does not depend on the sequence preference of a PBD molecule for a particular binding site, the rate of re-formation of the PBD-DNA adduct does. We have also shown that the PBD anthramycin (2) appears to be an exception to this rule in that, during cleavage from the DNA, its C-ring aromatizes and it cannot then re-attach due to a loss of electrophilicity at the C11-position. Although the C-ring aromatization of anthramycin has been previously reported to occur in the absence of DNA and after treatment with trifluoroacetic acid (TFA), in this case no pH lowering was required, with the DNA itself appearing to catalyse the process. The Royal Society of Chemistry 2011.
