77169-13-2

Upstream product

• 77635-72-4 1-(4-nitro-phenyl)-ethanone-phenylhydrazone 
• 59-88-1 phenylhydrazine hydrochloride 
• 21487-49-0 3-(4-nitrophenyl)-1-phenyl-1H-pyrazole-4-carbaldehyde 

Downstream Products

• 1380571-36-7 N-(4-chlorophenyl)-3-(4-nitrophenyl)-1-phenyl-1H-pyrazole-4-carboxamide 
• 1380571-38-9 N-(4-methoxylphenyl)-3-(4-nitrophenyl)-1-phenyl-1H-pyrazole-4-carboxamide 
• 1380571-35-6 3-(4-nitrophenyl)-N,1-diphenyl-1H-pyrazole-4-carboxamide 
• 1380571-39-0 N-(4-ethoxyphenyl)-3-(4-nitrophenyl)-1-phenyl-1H-pyrazole-4-carboxamide 
• 1380571-37-8 N-(4-bromophenyl)-3-(4-nitrophenyl)-1-phenyl-1H-pyrazole-4-carboxamide 

Relevant academic research and scientific papers

INHIBITOR COMPOUNDS FOR MALE CONTRACEPTION

Pyrazole compounds and piperazine compounds that are inhibitors of ALDH1A1 and ALDH1A2 and methods for using the pyrazole compounds and piperazine compounds in male contraceptive compositions for preventing spermatogenesis.

Synthesis, biological evaluation, and molecular docking studies of N,1,3-triphenyl-1H-pyrazole-4-carboxamide derivatives as anticancer agents

A series of N,1,3-triphenyl-1H-pyrazole-4-carboxamide derivatives have been designed, synthesized and evaluated for their potential antiproliferation activity and Aurora-A kinase inhibitory activity. Among all the compounds, compound 10e possessed the most potent biological activity against HCT116 and MCF-7 cell lines with IC50 values of 0.39 ± 0.06 μM and 0.46 ± 0.04 μM, respectively, which were comparable to the positive control. Compound 10e also exhibited significant Aurora-A kinase inhibitory activity (IC50 = 0.16 ± 0.03 μM). Docking simulation was performed to position compound 10e into the active site of Aurora-A kinase, in order to get the probable binding model for further study. The results of Western-blot assay demonstrated that compound 10e possessed good Aurora-A kinase inhibitory activity against HCT116. Based on the preliminary results, it is deduced that compound 10e with potent Aurora-A kinase inhibitory activity may be a potential anticancer agent.