7718-80-1Relevant academic research and scientific papers
Synthesis of 1-(4-substituted)benzyl-6-hydroxyisoquinolines with potential activity on Na+,K+-ATPase
Cerri,Mauri,Mauro,Melloni
, p. 1581 - 1592 (2007/10/02)
The synthesis of 1-(4-substituted)benzyl-6-hydroxyisoquinolines, to be evaluated in the displacement of the specific 3H-ouabain binding to Na+,K+-ATPase, is described. The key step involved a cyclization to the isoquinoline ring under Piclet-Gams conditions which was best performed with the 6-hydroxy group protected as the benzyl ether. When an unsaturated ester group was present in position 4 of the 1-benzyl group, this was best introduced before the cyclization step, since the Heck reaction on 1-(4- bromobenzyl)-6-hydroxyisoquinoline (8) with acrylic acid derivatives was not successful in all cases.
