77198-46-0

Upstream product

• 108-94-1 cyclohexanone 
• 785-80-8 p-nitrobenzylideneaniline 
• 109-77-3 malononitrile 
• 555-16-8 4-nitrobenzaldehdye 
• 4354-73-8 2-(cyclohexylidene)malononitrile 
• 2700-23-4 4-Nitrobenzylidenemalononitrile 

Relevant academic research and scientific papers

Synthesis of 1H-isochromenes, 4H-chromenes, and ortho-aminocarbonitrile tetrahydronaphthalenes from the same reactants by using metal-free catalyst

A facile and rapid multicomponent synthesis of pharmaceutically diverse 1H-isochromenes, 4H-chromenes, and ortho-aminocarbonitrile tetrahydronaphthalenes has been developed from benzaldehyde, malononitrile, and cyclohexanone. Three different methods from the same reactants, solvent, temperature, and catalyst lead to three products with excellent yields. All the reactions were followed with the Michael addition and cyclization. In this study, morpholine was used as an active metal-free base catalyst that increases the yields of products and decreases the time of reactions.

[MerDABCO-BSA][HSO4]2: A novel polymer supported Br?nsted acidic ionic liquid catalyst for the synthesis of biscoumarins and ortho-aminocarbonitriles

In the present work, a novel polymer supported Br?nsted acidic ionic liquid catalyst is synthesized by functionalization of Merrifield resin with DABCO, 1,4-butane sultone and concentrated H2SO4 is reported. The structure of synthesized catalyst was confirmed by FT-IR, SEM, EDX, XRD, XPS, TGA and DTA techniques. The catalytic efficiency of novel Br?nsted acidic [MerDABCO-BSA][HSO4]2 was evaluated in the synthesis of biscoumarins from 4-hydroxycoumarin and aryl aldehydes in ethanol at 80 °C. Also, ortho-aminocarbonitriles were synthesized from cyclohexanone, malononitrile and aromatic aldehydes in ethanol:water (70:30 v/v) under ultrasonic condition. The catalyst exhibits good stability under thermal as well as ultrasonic conditions. The recycled catalyst demonstrated good catalytic efficiency for four cycles without significant deterioration in the catalytic activity. The present protocol offers advantages of operational simplicity, shorter reaction times and higher yields of the products.

Synthesis of cobalt tetra-2,3-pyridiniumporphyrazinato with sulfonic acid tags as an efficient catalyst and its application for the synthesis of bicyclic: Ortho -aminocarbonitriles, cyclohexa-1,3-dienamines and 2-amino-3-cyanopyridines

Cobalt tetra-2,3-pyridiniumporphyrazinato with sulfonic acid tag [Co(TPPASO3H)]Cl was produced and catalyzed the synthesis of ortho-aminocarbonitriles, cyclohexa-1,3-dienamines and 2-amino-3-cyanopyridines. The synthesis of 2-amino-3-cyanopyridines by usi

CYCLIZATION REACTIONS OF NITRILES. III. SYNTHESIS OF o-CYANOANILINES BY THE THORPE REACTION

The reaction of alkylidenemalononitriles with arylidene derivatives of malononitrile and cyanoacetic ester leads to the formation of derivatives of 1-amino-2,6-dicyano-3,5-diaryl-1,3-cyclohexadiene or 2,4-dicyano-3-amino-5-arylbicyclodeca-2,10-dien